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Inhibitor Report for: Ro-2-0683

Specific inhibitor of BChE, used for phenotyping K and Atypical variants. Entry of reference human-BCHE


General
Type Trimethylammonium, Carbamate
Chemical_Nomenclature [2-(dimethylcarbamoyloxy)-5-phenylphenyl]methyl-trimethylazanium;bromide
Canonical SMILES CN(C)C(=O)OC1=C(C=C(C=C1)C2=CC=CC=C2)C[N+](C)(C)C.[Br-]
InChI InChI=1S/C19H25N2O2.BrH/c1-20(2)19(22)23-18-12-11-16(15-9-7-6-8-10-15)13-17(18)14-21(3,4)5;/h6-13H,14H2,1-5H3;1H/q+1;/p-1
InChIKey BKQQATFNHNQNJL-UHFFFAOYSA-M
Other name(s) RO2-0683 ; RO 20683 ; Ro-02-0683 ; dimethyl carbamate of (2-hydroxy-5-phenylbenzyl)-trimethyl-ammonium bromide ; Nu-683 ; NSC 306692 ; Ro 2-0683 ; (2-Hydroxy-5-phenylbenzyl)trimethylammonium bromide
________________________________________________________________________________________________
MW|393.318
Formula|C19H25BrN2O2
CAS_number|1954-17-2
PubChem|164903
UniChem|BKQQATFNHNQNJL-UHFFFAOYSA-M
IUPHAR|
Wikipedia|

Target
Families | Ro-2-0683 ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: Ro-2-0683

16 more
    Title: An explanation for the different inhibitory characteristics of human serum butyrylcholinesterase phenotypes deriving from inhibition of atypical heterozygotes
    Simeon-Rudolf V, Kovarik Z, Skrinjaric-Spoljar M, Evans RT
    Ref: Chemico-Biological Interactions, 119-120:159, 1999 : PubMed

            

    Title: Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide
    Whittaker M, Britten JJ
    Ref: Hum Hered, 31:242, 1981 : PubMed

            

    Title: The activity of various esterase inhibitors towards atypical human serum cholinesterase
    Kalow W, Davies R0
    Ref: Biochemical Pharmacology, 1:183, 1958 : PubMed

            


human-BCHE
MutationKiKsiIc50SubstrateConditionPaper
D70G - - 170 nM   Lockridge_1990_Pharmacol.Ther_47_35
WT - - 1.4 nM   Lockridge_1990_Pharmacol.Ther_47_35

WT Kinetics
Kinetic parametersKiKsiIc50SubstrateConditionsPapers
human-BCHE--1.4 nM  Lockridge_1990_Pharmacol.Ther_47_35