Riluzole
Riluzole is a benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. Has an inhibitory effect on glutamate release, inactivation of voltage-dependent sodium channels, and interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission.
General
Type : Drug,Benzothiazol,Trifluoro,Sulfur Compound,Not A\/B H target,Fragment inhibitor of Notum
Chemical_Nomenclature : 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
Canonical SMILES : C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
InChI : InChI=1S\/C8H5F3N2OS\/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5\/h1-3H,(H2,12,13)
InChIKey : FTALBRSUTCGOEG-UHFFFAOYSA-N
Other name(s) : Rilutek,2-Amino-6-(trifluoromethoxy)benzothiazole,6-(trifluoromethoxy)benzo[d]thiazol-2-amine,CHEMBL744,CHEBI:8863,SCHEMBL78905,ZINC6481,657
MW : 234.20
Formula : C8H5F3N2OS
CAS_number : 1744-22-5
PubChem : 5070
UniChem : FTALBRSUTCGOEG-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Riluzole ligand of proteins in family: Pectinacetylesterase-Notum
Stucture : 7BNJ Human Notum complexed with Riluzole
Protein : human-NOTUM
References (6)
| Title : Riluzole ameliorates learning and memory deficits in Abeta25-35-induced rat model of Alzheimer's disease and is independent of cholinoceptor activation - Mokhtari_2016_Biomed.Pharmacother_87_135 |
| Author(s) : Mokhtari Z , Baluchnejadmojarad T , Nikbakht F , Mansouri M , Roghani M |
| Ref : Biomed Pharmacother , 87 :135 , 2016 |
| Abstract : Mokhtari_2016_Biomed.Pharmacother_87_135 |
| ESTHER : Mokhtari_2016_Biomed.Pharmacother_87_135 |
| PubMedSearch : Mokhtari_2016_Biomed.Pharmacother_87_135 |
| PubMedID: 28049095 |
| Title : Pharmacological investigation of memory restorative effect of riluzole in mice - Rinwa_2012_Indian.J.Pharmacol_44_366 |
| Author(s) : Rinwa P , Jaggi AS , Singh N |
| Ref : Indian J Pharmacol , 44 :366 , 2012 |
| Abstract : Rinwa_2012_Indian.J.Pharmacol_44_366 |
| ESTHER : Rinwa_2012_Indian.J.Pharmacol_44_366 |
| PubMedSearch : Rinwa_2012_Indian.J.Pharmacol_44_366 |
| PubMedID: 22701248 |
| Title : Riluzole for motor neurone disease. More trials are needed - |
| Author(s) : Sandercock J , Burls A , Hyde C , Fry-Smith A , Barton P , Bryan S , Stewart A |
| Ref : BMJ , 322 :1305 , 2001 |
| PubMedID: 11403060 |
| Title : Selective inhibition by riluzole of voltage-dependent sodium channels and catecholamine secretion in adrenal chromaffin cells - Yokoo_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_526 |
| Author(s) : Yokoo H , Shiraishi S , Kobayashi H , Yanagita T , Yamamoto R , Wada A |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 357 :526 , 1998 |
| Abstract : Yokoo_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_526 |
| ESTHER : Yokoo_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_526 |
| PubMedSearch : Yokoo_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_526 |
| PubMedID: 9650805 |
| Title : Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration - Palfi_1997_Exp.Neurol_146_135 |
| Author(s) : Palfi S , Riche D , Brouillet E , Guyot MC , Mary V , Wahl F , Peschanski M , Stutzmann JM , Hantraye P |
| Ref : Experimental Neurology , 146 :135 , 1997 |
| Abstract : Palfi_1997_Exp.Neurol_146_135 |
| ESTHER : Palfi_1997_Exp.Neurol_146_135 |
| PubMedSearch : Palfi_1997_Exp.Neurol_146_135 |
| PubMedID: 9225746 |