Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: RG6

General
Type Strigolactone receptors ligand
Chemical_Nomenclature 2-[1-[(4-ethoxyphenyl)methyl]-4-[3-(4-methoxyphenyl)prop-2-enyl]piperazin-2-yl]ethanol
Canonical SMILES CCOC1=CC=C(C=C1)CN2CCN(CC2CCO)CC=CC3=CC=C(C=C3)OC
InChI InChI=1S/C25H34N2O3/c1-3-30-25-12-8-22(9-13-25)19-27-17-16-26(20-23(27)14-18-28)15-4-5-21-6-10-24(29-2)11-7-21/h4-13,23,28H,3,14-20H2,1-2H3/b5-4+/t23-/m0/s1
InChIKey MBXADFLSFSJJOZ-UHFFFAOYSA-N MBXADFLSFSJJOZ-OIUIXCLQSA-N
Other name(s) MCULE-8511489798 ; HFJ ; 2-{(2S)-1-[(4-ethoxyphenyl)methyl]-4-[(2E)-3-(4-methoxyphenyl)prop-2-en-1-yl]piperazin-2-yl}ethan-1-ol ; 2-[1-[(4-ethoxyphenyl)methyl]-4-[(~{E})-3-(4-methoxyphenyl)prop-2-enyl]piperazin-2-yl]ethanol ; ZINC22913448
________________________________________________________________________________________________
MW|410.5
Formula|C25H34N2O3
CAS_number|
PubChem|72076803, 30722494
UniChem|MBXADFLSFSJJOZ-UHFFFAOYSA-N, MBXADFLSFSJJOZ-OIUIXCLQSA-N
IUPHAR|
Wikipedia|

Target
Families | RG6 ligand of proteins in family: RsbQ-like
Stucture | 1 structure: 7SNU: Crystal structure of ShHTL7 from Striga hermonthica in complex with strigolactone antagonist RG6
Protein | strhe-ShHTL7

References:
Search PubMed for references concerning: RG6
    Title: A novel strigolactone receptor antagonist provides insights into the structural inhibition, conditioning, and germination of the crop parasite Striga
    Arellano-Saab A, McErlean CSP, Lumba S, Savchenko A, Stogios PJ, McCourt P
    Ref: Journal of Biological Chemistry, :101734, 2022 : PubMed

            

    Title: Small-molecule antagonists of germination of the parasitic plant Striga hermonthica
    Holbrook-Smith D, Toh S, Tsuchiya Y, McCourt P
    Ref: Nat Chemical Biology, 12:724, 2016 : PubMed