Inhibitor Report for: Pyrimidinone-inhibitor3 General
Type Pyrimidine , Cyanide Chemical_Nomenclature 2-[[2-[(3R)-3-aminopiperidin-1-ium-1-ylidene]-5-bromo-4-oxo-1H-pyrimidin-3-yl]methyl]benzonitrile Canonical SMILES C1CC(C[N+](=C2NC=C(C(=O)N2CC3=CC=CC=C3C#N)Br)C1)N InChI InChI=1S/C17H18BrN5O/c18-15-9-21-17(22-7-3-6-14(20)11-22)23(16(15)24)10-13-5-2-1-4-12(13)8-19/h1-2,4-5,9,14H,3,6-7,10-11,20H2/p+1/t14-/m1/s1 InChIKey GGCILSXUAHLDMF-CQSZACIVSA-O Other name(s) RUM
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Target
Families | Pyrimidinone-inhibitor3 ligand of proteins in family: DPP4N_Peptidase_S9 Stucture | 1 structure : 3G0G : Crystal structure of Dipeptidyl Peptidase IV in complex with a pyrimidinone inhibitor Protein | human-DPP4
References:
Title: Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IVZhang Z , Wallace MB , Feng J , Stafford JA , Skene RJ , Shi L , Lee B , Aertgeerts K , Jennings A and Gwaltney SL <5 more author(s)> Zhang Z , Wallace MB , Feng J , Stafford JA , Skene RJ , Shi L , Lee B , Aertgeerts K , Jennings A , Xu R , Kassel DB , Kaldor SW , Navre M , Webb DR , Gwaltney SL (- 5) Ref: Journal of Medicinal Chemistry, 54 :510, 2011 : PubMed Abstract ESTHER: Zhang_2011_J.Med.Chem_54_510 PubMedSearch: Zhang 2011 J.Med.Chem 54 510 PubMedID: 21186796 Gene_locus related to this paper: human-DPP4 Inhibitor(s) related to this paper: Pyrimidinone-inhibitor1 ,
Pyrimidinone-inhibitor3 ,
Xanthine-inhibitor-4 ,
CHEMBL2159182 ,
Alogliptin Abstract
The discovery of two classes of heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyrimidinediones, is described. After a single oral dose, these potent, selective, and noncovalent inhibitors provide sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes. Compounds 13a, 27b, and 27j were selected for development.
