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Inhibitor Report for: Physovenine

General
Type Carbamate, Natural
Chemical_Nomenclature 2H-Furo(2,3-b)indol-5-ol, 3,3a,8,8a-tetrahydro-3a,8-dimethyl-, methylcarbamate (ester), (3aS-cis)
Canonical SMILES CC12CCOC1N(C3=C2C=C(C=C3)OC(=O)NC)C
InChI InChI=1S/C14H18N2O3/c1-14-6-7-18-12(14)16(3)11-5-4-9(8-10(11)14)19-13(17)15-2/h4-5,8,12H,6-7H2,1-3H3,(H,15,17) InChI=1S/C14H18N2O3/c1-14-6-7-18-12(14)16(3)11-5-4-9(8-10(11)14)19-13(17)15-2/h4-5,8,12H,6-7H2,1-3H3,(H,15,17)/t12-,14-/m0/s1
InChIKey LXTKNVLLWOLCOV-UHFFFAOYSA-N LXTKNVLLWOLCOV-JSGCOSHPSA-N
Other name(s) (-)-Physovenine ; 6091-05-0 ; 3a,8-Dimethyl-3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indol-5-yl methylcarbamate ; 2H-Furo(2,3-b)indol-5-ol, 3,3a,8,8a-tetrahydro-3a,8-dimethyl-, methylcarbamate (ester), (3aS-cis)- ; 2H-Furo[2,3-b]indol-5-ol, 3,3a,8,8a-tetrahydro-3a,8-dimethyl-, methylcarbamate (ester), (3aS-cis)-
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MW|262
Formula|C14H18N2O3
CAS_number|6091-05-0
PubChem|110765, 442113
UniChem|LXTKNVLLWOLCOV-UHFFFAOYSA-N, LXTKNVLLWOLCOV-JSGCOSHPSA-N
IUPHAR|
Wikipedia|

Target
Families | Physovenine ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Physovenine

2 more
    Title: An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine
    ElAzab AS, Taniguchi T, Ogasawara K
    Ref: Org Lett, 2:2757, 2000 : PubMed

            

    Title: The role of TRP84 in catalytic power and the specificity of AChE
    Pomponi M, Sacchi S, Colella A, Patamia M, Marta M
    Ref: Biophysical Chemistry, 72:239, 1998 : PubMed

            

    Title: Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease
    Greig NH, Pei XF, Soncrant TT, Ingram DK, Brossi A
    Ref: Med Res Rev, 15:3, 1995 : PubMed