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Phenyl-di-n-pentylphosphinate

Phenyl di-n-pentylphosphinate PPP is a potent inhibitor of neuropathy target esterase NTE with negligible effect on acetylcholinesterase

General

Type : Organophosphate,NTE inhibitor,Not A\/B H target

Chemical_Nomenclature : dipentylphosphoryloxybenzene

Canonical SMILES : CCCCCP(=O)(CCCCC)OC1=CC=CC=C1

InChI : InChI=1S\/C16H27O2P\/c1-3-5-10-14-19(17,15-11-6-4-2)18-16-12-8-7-9-13-16\/h7-9,12-13H,3-6,10-11,14-15H2,1-2H3

InChIKey : TUJWIYZCAPMHSA-UHFFFAOYSA-N

Other name(s) : Phenyl di-n-pentylphosphinate,PDNP,PDPP,Phenyl dipentylphosphinate,Dipentylphosphoryloxybenzene

MW : 282.35

Formula : C16H27O2P

CAS_number :

PubChem : 151930

UniChem : TUJWIYZCAPMHSA-UHFFFAOYSA-N

Target

References (2)

Title : Phospholipase B activity and organophosphorus compound toxicity in cultured neural cells - Read_2007_Toxicol.Appl.Pharmacol_219_190
Author(s) : Read DJ , Langford L , Barbour HR , Forshaw PJ , Glynn P
Ref : Toxicol Appl Pharmacol , 219 :190 , 2007
Abstract : Read_2007_Toxicol.Appl.Pharmacol_219_190
ESTHER : Read_2007_Toxicol.Appl.Pharmacol_219_190
PubMedSearch : Read_2007_Toxicol.Appl.Pharmacol_219_190
PubMedID: 16963094

Title : Prophylaxis against and promotion of organophosphate-induced delayed neuropathy by phenyl di-n-pentylphosphinate - Johnson_1993_Chem.Biol.Interact_87_449
Author(s) : Johnson MK , Read DJ
Ref : Chemico-Biological Interactions , 87 :449 , 1993
Abstract : Johnson_1993_Chem.Biol.Interact_87_449
ESTHER : Johnson_1993_Chem.Biol.Interact_87_449
PubMedSearch : Johnson_1993_Chem.Biol.Interact_87_449
PubMedID: 8344002 
Array
(
    [id] => 5475
    [inhibitor] => Phenyl-di-n-pentylphosphinate
    [type] => Array
        (
            [0] => Organophosphate
            [1] => NTE inhibitor
            [2] => Not A\/B H target
        )

    [other_name] => Array
        (
            [0] => Phenyl di-n-pentylphosphinate
            [1] => PDNP
            [2] => PDPP
            [3] => Phenyl dipentylphosphinate
            [4] => Dipentylphosphoryloxybenzene
        )

    [chemical_nomenclature] => dipentylphosphoryloxybenzene
    [formula] => C16H27O2P
    [cas_number] => 
    [mw] => 282.35
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Johnson_1993_Chem.Biol.Interact_87_449 || Read_2007_Toxicol.Appl.Pharmacol_219_190
    [comment] => Phenyl di-n-pentylphosphinate PPP is a potent inhibitor of neuropathy target esterase NTE with negligible effect on acetylcholinesterase
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 151930
    [family] => 
    [inchikey] => TUJWIYZCAPMHSA-UHFFFAOYSA-N
    [canonicalsmiles] => CCCCCP(=O)(CCCCC)OC1=CC=CC=C1
    [inchi] => InChI=1S\/C16H27O2P\/c1-3-5-10-14-19(17,15-11-6-4-2)18-16-12-8-7-9-13-16\/h7-9,12-13H,3-6,10-11,14-15H2,1-2H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
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)