Perphenazine
dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ),
General
Type : Phenothiazine,Sulfur Compound,Not A\/B H target
Chemical_Nomenclature : 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
Canonical SMILES : C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO
InChI : InChI=1S\/C21H26ClN3OS\/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26\/h1-2,4-7,16,26H,3,8-15H2
InChIKey : RGCVKNLCSQQDEP-UHFFFAOYSA-N
Other name(s) : Trilafon,Perphenazin,Etaperazine,CHEMBL567,CHEBI:8028,SCHEMBL42125,ZINC19228902
MW : 404.0
Formula : C21H26ClN3OS
CAS_number : 58-39-9
PubChem : 4748
UniChem : RGCVKNLCSQQDEP-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families :
Stucture :
Protein :
References (7)
| Title : Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review - Otreba_2020_Eur.J.Pharmacol_887_173553 |
| Author(s) : Otreba M , Kosmider L , Rzepecka-Stojko A |
| Ref : European Journal of Pharmacology , 887 :173553 , 2020 |
| Abstract : Otreba_2020_Eur.J.Pharmacol_887_173553 |
| ESTHER : Otreba_2020_Eur.J.Pharmacol_887_173553 |
| PubMedSearch : Otreba_2020_Eur.J.Pharmacol_887_173553 |
| PubMedID: 32949606 |
| Title : Inactivation of cholinesterase induced by chlorpromazine cation radicals - Muraoka_2003_Pharmacol.Toxicol_92_100 |
| Author(s) : Muraoka S , Miura T |
| Ref : Pharmacol Toxicol , 92 :100 , 2003 |
| Abstract : Muraoka_2003_Pharmacol.Toxicol_92_100 |
| ESTHER : Muraoka_2003_Pharmacol.Toxicol_92_100 |
| PubMedSearch : Muraoka_2003_Pharmacol.Toxicol_92_100 |
| PubMedID: 12747580 |
| Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 |
| Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T |
| Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002 |
| Abstract : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 |
| ESTHER : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 |
| PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 |
| PubMedID: 12443046 |
| Title : Pharmacologic profile of perphenazine's metabolites - Sweet_2000_J.Clin.Psychopharmacol_20_181 |
| Author(s) : Sweet RA , Pollock BG , Mulsant BH , Rosen J , Sorisio D , Kirshner M , Henteleff R , DeMichele MA |
| Ref : J Clin Psychopharmacol , 20 :181 , 2000 |
| Abstract : Sweet_2000_J.Clin.Psychopharmacol_20_181 |
| ESTHER : Sweet_2000_J.Clin.Psychopharmacol_20_181 |
| PubMedSearch : Sweet_2000_J.Clin.Psychopharmacol_20_181 |
| PubMedID: 10770456 |
| Title : Quantitative determination of perphenazine and its metabolites in plasma by high-performance liquid chromatography and coulometric detection - Foglia_1995_J.Chromatogr.B.Biomed.Appl_668_291 |
| Author(s) : Foglia JP , Sorisio D , Kirshner MA , Mulsant BH , Perel JM |
| Ref : Journal of Chromatography B Biomed Appl , 668 :291 , 1995 |
| Abstract : Foglia_1995_J.Chromatogr.B.Biomed.Appl_668_291 |
| ESTHER : Foglia_1995_J.Chromatogr.B.Biomed.Appl_668_291 |
| PubMedSearch : Foglia_1995_J.Chromatogr.B.Biomed.Appl_668_291 |
| PubMedID: 7581864 |
| Title : Phenothiazines inhibit acetylcholinesterase by concentration-dependent-type kinetics. A study with trifluoperazine and perphenazine - Spinedi_1992_Biochem.Pharmacol_44_1511 |
| Author(s) : Spinedi A , Pacini L , Limatola C , Luly P , Farias RN |
| Ref : Biochemical Pharmacology , 44 :1511 , 1992 |
| Abstract : Spinedi_1992_Biochem.Pharmacol_44_1511 |
| ESTHER : Spinedi_1992_Biochem.Pharmacol_44_1511 |
| PubMedSearch : Spinedi_1992_Biochem.Pharmacol_44_1511 |
| PubMedID: 1417975 |
| Title : Differential effect of anionic and cationic drugs on the synaptosome-associated acetylcholinesterase activity of dog brain - Deliconstantinos_1985_Biochem.J_229_81 |
| Author(s) : Deliconstantinos G , Tsakiris S |
| Ref : Biochemical Journal , 229 :81 , 1985 |
| Abstract : Deliconstantinos_1985_Biochem.J_229_81 |
| ESTHER : Deliconstantinos_1985_Biochem.J_229_81 |
| PubMedSearch : Deliconstantinos_1985_Biochem.J_229_81 |
| PubMedID: 4038267 |