The incorporation of a synthetic, catalytically competent metallo cofactor into a protein scaffold to generate an artificial metalloenzyme (ArM) lead to new activities specific of the cofactor
Type : Organophosphate,Pincer-Metal-cofactor
Chemical_Nomenclature : 3-[3,5-bis[(dimethylamino)methyl]benzene-4-id-1-yl]propyl-ethoxyphosphinic acid\;chloroplatinum
Canonical SMILES : CCOP(=O)(CCCC1=CC(=[C-]C(=C1)CN(C)C)CN(C)C)O.Cl[Pt]
InChI : InChI=1S\/C17H30N2O3P.ClH.Pt\/c1-6-22-23(20,21)9-7-8-15-10-16(13-18(2)3)12-17(11-15)14-19(4)5\;\;\/h10-11H,6-9,13-14H2,1-5H3,(H,20,21)\;1H\;\/q-1\;\;+1\/p-1
InChIKey : HKSIINDLAPYCJN-UHFFFAOYSA-M
Other name(s) : (2,6-Bis[(Dimethylamino-Kappan)methyl]-4-{3-[(S)-Ethoxy(4-Nitrophenoxy)phosphoryl]propyl}phenyl-Kappac~1~)(Chloro)platinum(2+),NXC,NCN-Pt-Pincer
MW : 571.94
Formula : C17H30ClN2O3PPt-
CAS_number :
PubChem : 44129613
UniChem : HKSIINDLAPYCJN-UHFFFAOYSA-M
IUPHAR :
Wikipedia :
Title : Solid-state structural characterization of cutinase-ECE-pincer-metal hybrids - Rutten_2009_Chemistry_15_4270 |
Author(s) : Rutten L , Wieczorek B , Mannie JP , Kruithof CA , Dijkstra HP , Egmond MR , Lutz M , Klein Gebbink RJ , Gros P , van Koten G |
Ref : Chemistry , 15 :4270 , 2009 |
Abstract : Rutten_2009_Chemistry_15_4270 |
ESTHER : Rutten_2009_Chemistry_15_4270 |
PubMedSearch : Rutten_2009_Chemistry_15_4270 |
PubMedID: 19219875 |
Gene_locus related to this paper: fusso-cutas |
Title : Lipase active-site-directed anchoring of organometallics: metallopincer\/protein hybrids - Kruithof_2005_Chemistry_11_6869 |
Author(s) : Kruithof CA , Casado MA , Guillena G , Egmond MR , van der Kerk-van Hoof A , Heck AJ , Klein Gebbink RJ , van Koten G |
Ref : Chemistry , 11 :6869 , 2005 |
Abstract : Kruithof_2005_Chemistry_11_6869 |
ESTHER : Kruithof_2005_Chemistry_11_6869 |
PubMedSearch : Kruithof_2005_Chemistry_11_6869 |
PubMedID: 16224766 |
Gene_locus related to this paper: fusso-cutas |