ESTHER Database

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Inhibitor

Inhibitor Report for: NF595

very similar to Bis7-tacrine

General

Type		Derivative of Tacrine, Alkyl linked bis-ligand, Sulfur Compound
Chemical_Nomenclature		N-[8-(1,2,3,4-tetrahydroacridin-9-ylsulfanyl)octyl]-1,2,3,4-tetrahydroacridin-9-amine
Canonical SMILES		C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCCCSC4=C5CCCCC5=NC6=CC=CC=C64
InChI		InChI=1S/C34H41N3S/c1(3-13-23-35-33-25-15-5-9-19-29(25)36-30-20-10-6-16-26(30)33)2-4-14-24-38-34-27-17-7-11-21-31(27)37-32-22-12-8-18-28(32)34/h5,7,9,11,15,17,19,21H,1-4,6,8,10,12-14,16,18,20,22-24H2,(H,35,36)
InChIKey		COEYCPFFRLYNSC-UHFFFAOYSA-N
Other name(s)		CHEMBL129108 ; N8T ; N-[8-(1,2,3,4-tetrahydroacridin-9-ylsulfanyl)octyl]-1,2,3,4-tetrahydroacridin-9-amine ; Tacrine Dimer 4g ; AC1O70TL ; BDBM8971

________________________________________________________________________________________________

MW	\|	523.77
Formula	\|	C34H41N3S
CAS_number	\|
PubChem	\|	6540271
UniChem	\|	COEYCPFFRLYNSC-UHFFFAOYSA-N
IUPHAR	\|
Wikipedia	\|

Target

Families	\|	NF595 ligand of proteins in family: ACHE
Stucture	\|	1 structure: 2CEK: Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor
Protein	\|	torca-ACHE

References:

Search PubMed for references concerning: NF595

Title:

Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M

Ref:

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