N-octyl-tacrine
Tricyclic amine-containing compound, other alkyl derivative exist heptyl pentyl butyl (bucricaine). The CID ref here is a chloro derivative
General
Type : Derivative of Tacrine,Acridine
Chemical_Nomenclature : N-Octyl-1,2,3,4-tetrahydroacridin-9-amine
Canonical SMILES : CCCCCCCCNC1=C2CCCCC2=NC3=C1C=CC(=C3)Cl || CCCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31
InChI : InChI=1S\/C21H29ClN2\/c1-2-3-4-5-6-9-14-23-21-17-10-7-8-11-19(17)24-20-15-16(22)12-13-18(20)21\/h12-13,15H,2-11,14H2,1H3,(H,23,24) || InChI=1S\/C21H30N2\/c1-2-3-4-5-6-11-16-22-21-17-12-7-9-14-19(17)23-20-15-10-8-13-18(20)21\/h7,9,12,14H,2-6,8,10-11,13,15-16H2,1H3,(H,22,23)
InChIKey : QVWXYBWSALRXJY-UHFFFAOYSA-N || YBNDUUUQKSTMNR-UHFFFAOYSA-N
Other name(s) : THA-C8,CHEMBL2393100,N-octyl-1,2,3,4-tetrahydroacridin-9-amine,CHEMBL214225,SCHEMBL7674463,9-Acridinamine, 1,2,3,4-tetrahydro-N-octyl-
MW : 344.92 || 310.5
Formula : C21H29ClN2 || C21H30N2
CAS_number : 1440519-83-4
UniChem : QVWXYBWSALRXJY-UHFFFAOYSA-N || YBNDUUUQKSTMNR-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (4)
| Title : Investigation of the role of linker moieties in bifunctional tacrine hybrids - Eckroat_2013_Bioorg.Med.Chem_21_3614 |
| Author(s) : Eckroat TJ , Green KD , Reed RA , Bornstein JJ , Garneau-Tsodikova S |
| Ref : Bioorganic & Medicinal Chemistry , 21 :3614 , 2013 |
| Abstract : Eckroat_2013_Bioorg.Med.Chem_21_3614 |
| ESTHER : Eckroat_2013_Bioorg.Med.Chem_21_3614 |
| PubMedSearch : Eckroat_2013_Bioorg.Med.Chem_21_3614 |
| PubMedID: 23535563 |
| Title : The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory - Hornick_2011_Neurosci_197_280 |
| Author(s) : Hornick A , Lieb A , Vo NP , Rollinger JM , Stuppner H , Prast H |
| Ref : Neuroscience , 197 :280 , 2011 |
| Abstract : Hornick_2011_Neurosci_197_280 |
| ESTHER : Hornick_2011_Neurosci_197_280 |
| PubMedSearch : Hornick_2011_Neurosci_197_280 |
| PubMedID: 21945033 |
| Title : Search of antitubercular activities in tetrahydroacridines: synthesis and biological evaluation - Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144 |
| Author(s) : Tripathi RP , Verma SS , Pandey J , Agarwal KC , Chaturvedi V , Manju YK , Srivastva AK , Gaikwad A , Sinha S |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5144 , 2006 |
| Abstract : Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144 |
| ESTHER : Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144 |
| PubMedSearch : Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144 |
| PubMedID: 16870429 |
| Title : Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3, 4- tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice - Capone_1999_Neurobiol.Learn.Mem_71_301 |
| Author(s) : Capone F , Oliverio A , Pomponi M , Marta M , Gatta F , Pavone F |
| Ref : Neurobiol Learn Mem , 71 :301 , 1999 |
| Abstract : Capone_1999_Neurobiol.Learn.Mem_71_301 |
| ESTHER : Capone_1999_Neurobiol.Learn.Mem_71_301 |
| PubMedSearch : Capone_1999_Neurobiol.Learn.Mem_71_301 |
| PubMedID: 10196108 |