Mylaxen
Hexafluronium bromide is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block the activity of plasma cholinesterases.
General
Type : Neuromuscular Nondepolarizing Agents,Drug,Fluoren
Chemical_Nomenclature : 9H-fluoren-9-yl-[6-[9H-fluoren-9-yl(dimethyl)azaniumyl]hexyl]-dimethylazanium\;dibromide
Canonical SMILES : C[N+](C)(CCCCCC[N+](C)(C)C1C2=CC=CC=C2C3=CC=CC=C13)C4C5=CC=CC=C5C6=CC=CC=C46.[Br-].[Br-]
InChI : InChI=1S\/C36H42N2.2BrH\/c1-37(2,35-31-21-11-7-17-27(31)28-18-8-12-22-32(28)35)25-15-5-6-16-26-38(3,4)36-33-23-13-9-19-29(33)30-20-10-14-24-34(30)36\;\;\/h7-14,17-24,35-36H,5-6,15-16,25-26H2,1-4H3\;2*1H\/q+2\;\;\/p-2
InChIKey : WDEFPRUEZRUYNW-UHFFFAOYSA-L
Other name(s) : Hexafluronium,Hexafluronium bromide,Hexafluorenium bromide,Milaxen,Hexafluorenium dibromide,Esafluronio bromuro
MW : 662.54
Formula : C36H42Br2N2
CAS_number : 4844-10-4
PubChem : 9434
UniChem : WDEFPRUEZRUYNW-UHFFFAOYSA-L
IUPHAR :
Wikipedia : Hexafluronium_bromide
Target
References (31)
| Title : Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats - Koller_1984_Acta.Anaesthesiol.Scand_28_87 |
| Author(s) : Koller ME , Breivik H , Greider P , Jones DJ , Smith RB |
| Ref : Acta Anaesthesiologica Scandinavica , 28 :87 , 1984 |
| Abstract : Koller_1984_Acta.Anaesthesiol.Scand_28_87 |
| ESTHER : Koller_1984_Acta.Anaesthesiol.Scand_28_87 |
| PubMedSearch : Koller_1984_Acta.Anaesthesiol.Scand_28_87 |
| PubMedID: 6711267 |
| Title : Prevention of succinylcholine induced hyperkalemia by neurolept anesthesia and hexafluorenium in anephric patients - Radnay_1981_Anaesthesist_30_334 |
| Author(s) : Radnay PA , El-Gaweet ES , Novakovic M , Badola R , Cizmar S , Duncalf D |
| Ref : Anaesthesist , 30 :334 , 1981 |
| Abstract : Radnay_1981_Anaesthesist_30_334 |
| ESTHER : Radnay_1981_Anaesthesist_30_334 |
| PubMedSearch : Radnay_1981_Anaesthesist_30_334 |
| PubMedID: 6455928 |
| Title : Prevention of suxamethonium-induced changes in serum potassium concentration by hexafluorenium. Is their combined use justified? - Radnay_1979_Br.J.Anaesth_51_447 |
| Author(s) : Radnay PA , Badola RP , Dalsania A , El-Gaweet EI , Duncalf D |
| Ref : British Journal of Anaesthesia , 51 :447 , 1979 |
| Abstract : Radnay_1979_Br.J.Anaesth_51_447 |
| ESTHER : Radnay_1979_Br.J.Anaesth_51_447 |
| PubMedSearch : Radnay_1979_Br.J.Anaesth_51_447 |
| PubMedID: 444345 |
| Title : The desensitizing interaction of hexafluorenium with the cholinergic receptor in the diaphragm of the rat - Scaf_1977_Arch.Int.Pharmacodyn.Ther_225_196 |
| Author(s) : Scaf AH , Langendijk JW |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 225 :196 , 1977 |
| Abstract : Scaf_1977_Arch.Int.Pharmacodyn.Ther_225_196 |
| ESTHER : Scaf_1977_Arch.Int.Pharmacodyn.Ther_225_196 |
| PubMedSearch : Scaf_1977_Arch.Int.Pharmacodyn.Ther_225_196 |
| PubMedID: 849069 |
| Title : Interaction of hexafluorenium with human plasma cholinesterase in comparison with hexamethonium - Schuh_1976_Naunyn.Schmiedebergs.Arch.Pharmacol_293_11 |
| Author(s) : Schuh FR |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 293 :11 , 1976 |
| Abstract : Schuh_1976_Naunyn.Schmiedebergs.Arch.Pharmacol_293_11 |
| ESTHER : Schuh_1976_Naunyn.Schmiedebergs.Arch.Pharmacol_293_11 |
| PubMedSearch : Schuh_1976_Naunyn.Schmiedebergs.Arch.Pharmacol_293_11 |
| PubMedID: 948350 |
| Title : Hexafluorenium-suxamethonium interaction in patients with normal versus atypical cholinesterase - Baraka_1975_Br.J.Anaesth_47_885 |
| Author(s) : Baraka A |
| Ref : British Journal of Anaesthesia , 47 :885 , 1975 |
| Abstract : Baraka_1975_Br.J.Anaesth_47_885 |
| ESTHER : Baraka_1975_Br.J.Anaesth_47_885 |
| PubMedSearch : Baraka_1975_Br.J.Anaesth_47_885 |
| PubMedID: 1201167 |
| Title : The potentiation of the neuromuscular blocking activity of hexafluorenium and d-tubocurarine by volatile anaesthetics - |
| Author(s) : Vermeer GA , Hess SW |
| Ref : Anaesthesist , 23 :72 , 1974 |
| PubMedID: 4458482 |
| Title : The interactions of hexafluorenium with depolarizing and competitive neuromuscular blocking agents - |
| Author(s) : Scaf AH , van den Akker J , Berends F |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 208 :166 , 1974 |
| PubMedID: 4276930 |
| Title : The role of cholinesterase in the neuromuscular effects of succinylcholine, decamethonium and hexafluorenium - |
| Author(s) : Scaf AH , van den Akker J , Westenberg HG |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 208 :177 , 1974 |
| PubMedID: 4846189 |
| Title : Hexafluorenium bromide: current status and a review - |
| Author(s) : Britton RM , Figueroa M |
| Ref : Anesthesia & Analgesia , 52 :100 , 1973 |
| PubMedID: 4567515 |
| Title : The excretion of hexafluorenium in man and rat - |
| Author(s) : Meijer DK , Vermeer GA , Kwant G |
| Ref : European Journal of Pharmacology , 14 :280 , 1971 |
| PubMedID: 5156146 |
| Title : The cardiac glycoside sensitive step in the hepatic transport of the bisquaternary ammonium compound, hexafluorenium - |
| Author(s) : Meijer DK , Arends JW , Weitering JG |
| Ref : European Journal of Pharmacology , 15 :245 , 1971 |
| PubMedID: 5153849 |
| Title : Clinical studies of the interaction of hexafluorenium and succinylcholine in man - |
| Author(s) : Walts LF , DeAngelis J , Dillon JB |
| Ref : Anesthesiology , 33 :503 , 1970 |
| PubMedID: 4249163 |
| Title : Hexafluorenium-suxamethonium relaxation for abdominal surgery - |
| Author(s) : Campbell FN , Swerdlow M |
| Ref : British Journal of Anaesthesia , 41 :962 , 1969 |
| PubMedID: 5354795 |
| Title : The effect of hexafluorenium on the neuromuscular refractory period of anesthetized man - |
| Author(s) : Epstein RA , Jackson SH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 170 :153 , 1969 |
| PubMedID: 5350999 |
| Title : Hexafluorenium-succinylcholine in general anaesthesia - |
| Author(s) : Cecconello D , Fanchiotti GL , Giussani A |
| Ref : Acta Anaesthesiologica Scandinavica , 12 :31 , 1968 |
| PubMedID: 5750723 |
| Title : Succinylcholine-hexafluorenium combination for muscular relaxation: a reappraisal - |
| Author(s) : Figueroa M, Jr. |
| Ref : South Med J , 61 :808 , 1968 |
| PubMedID: 4385945 |
| Title : The interactions of neuromuscular blocking agents in man: the role of hexafluorenium - |
| Author(s) : Torda TA , Foldes FF , Bailey RJ , Klonymus DH , Kuwabara S |
| Ref : Anesthesiology , 28 :1010 , 1967 |
| PubMedID: 4383425 |
| Title : Investigation of the cardiovascular effects of hexafluorenium - |
| Author(s) : Duncalf D , Foldes FF , Jacobson E , Vargas PG |
| Ref : British Journal of Anaesthesia , 37 :591 , 1965 |
| PubMedID: 5831693 |
| Title : Hexafluorenium extension of suxamethonium block - |
| Author(s) : van Hemert VR , Pearce C |
| Ref : British Journal of Anaesthesia , 37 :585 , 1965 |
| PubMedID: 5319075 |
| Title : EXPERIMENTAL STUDY OF ARRHYTHMIAS AND BRONCHOSPASM ASSOCIATED WITH THE USE OF HEXAFLUORENIUM - |
| Author(s) : Mostert JW , Kuendig H |
| Ref : British Journal of Anaesthesia , 36 :83 , 1964 |
| PubMedID: 14117757 |
| Title : Hexafluorenium: its anticholinesterase and neuromuscular activity - |
| Author(s) : Foldes FF , Molloy RE , Zsigmond EK , Zwartz JA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 129 :400 , 1960 |
| PubMedID: 13823697 |
| Title : Potentiation of the neuromuscular effect of succinylcholine by hexafluorenium - |
| Author(s) : Foldes FF , Hillmer NR , Molloy RE , Monte AP |
| Ref : Anesthesiology , 21 :50 , 1960 |
| PubMedID: 13823695 |