Inhibitor Report for: Morpholino-Talinolol

Derivative of Talinolol unselective antagonist of the beta adrenergic receptors (betaAR). Much better inhibitor of soluble epoxide hydrolase than talinolol IC50 0.077+/-0.004 muM

General

Type		Urea derivative, Not A/B H target, Adrenergic-Receptor-ligand, Morpholine, tert-Butyl
Chemical_Nomenclature		1-[4-[[(2S)-4-tert-butylmorpholin-2-yl]methoxy]phenyl]-3-cyclohexylurea
Canonical SMILES		CC(C)(C)N1CCOC(C1)COC2=CC=C(C=C2)NC(=O)NC3CCCCC3
InChI		InChI=1S/C22H35N3O3/c1-22(2,3)25-13-14-27-20(15-25)16-28-19-11-9-18(10-12-19)24-21(26)23-17-7-5-4-6-8-17/h9-12,17,20H,4-8,13-16H2,1-3H3,(H2,23,24,26)/t20-/m0/s1
InChIKey		PSVUAGRHPQWOOO-FQEVSTJZSA-N
Other name(s)		G3T

________________________________________________________________________________________________

MW	\|	389.53
Formula	\|	C22H35N3O3
CAS_number	\|
PubChem	\|	138454247
UniChem	\|	PSVUAGRHPQWOOO-FQEVSTJZSA-N
IUPHAR	\|
Wikipedia	\|

Target

Families	\|	Morpholino-Talinolol ligand of proteins in family: Epoxide_hydrolase
Stucture	\|	1 structure: 6HGX: Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl)morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea
Protein	\|	human-EPHX2

References:

Search PubMed for references concerning: Morpholino-Talinolol

Title:

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G and Proschak E <7 more author(s)>

Ref:

PubMed