First synthetic carbamate to find clinical application due to its miotic activity. Eye drop. The hydrochlorid is cid=46092
Type : Carbamate,Derivative of Rivastigmine
Chemical_Nomenclature : [3-(1-dimethylaminoethyl)phenyl] methylaminoformate
Canonical SMILES : CC(C1=CC(=CC=C1)OC(=O)NC)[NH+](C)C.[Cl-] || CC(C1=CC(=CC=C1)OC(=O)NC)N(C)C
InChI : InChI=1S\/C12H18N2O2.ClH\/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2\;\/h5-9H,1-4H3,(H,13,15)\;1H || InChI=1S\/C12H18N2O2\/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2\/h5-9H,1-4H3,(H,13,15)
InChIKey : SXVZMCIGRIYWTD-UHFFFAOYSA-N || KQOUPMYYRQWZLI-UHFFFAOYSA-N
Other name(s) : AR-28,T-1843,Methylcarbamic ester of alpha-3-hydroxyphenylethyldimethylamine hydrochloride,Carbamic acid, N-methyl-, 3-(alpha-dimethylaminoethyl)phenyl ester, hydrochloride,Carbamic acid, N-methyl-, m-(alpha-dimethylaminoethyl)phenyl ester, hydrochloride,63982-32-1,C11763
MW : 222.284
Formula : C12H18N2O2
CAS_number :
UniChem : SXVZMCIGRIYWTD-UHFFFAOYSA-N || KQOUPMYYRQWZLI-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Miotine
Title : Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues - Bolognesi_2004_J.Med.Chem_47_5945 |
Author(s) : Bolognesi ML , Bartolini M , Cavalli A , Andrisano V , Rosini M , Minarini A , Melchiorre C |
Ref : Journal of Medicinal Chemistry , 47 :5945 , 2004 |
Abstract : Bolognesi_2004_J.Med.Chem_47_5945 |
ESTHER : Bolognesi_2004_J.Med.Chem_47_5945 |
PubMedSearch : Bolognesi_2004_J.Med.Chem_47_5945 |
PubMedID: 15537349 |
Title : Investigations on the influence of chemical constitution upon toxicity\; compounds related to miotine - |
Author(s) : Davies RE , Haworth RD , Jones B , Lamberton AH |
Ref : J Chem Soc , :191 , 1947 |
PubMedID: 20238647 |
Title : Chemical constitution and miotic action - |
Author(s) : Stedman E |
Ref : American Journal of Physiology , 90 :528 , 1929 |
PubMedID: |