Methylene-blue-carboline-2
Conjugates of methylene blue with gamma-carboline derivatives (Dimebon). Latrepirdine Dimebon tricyclic H1-antihistamine has been investigated for the treatment of Alzheimer's Disease and Huntington's Disease. The conjugate of Dimebon derivative and methylene blue 2 is represented here
General
Type : Dye,Multitarget,Indole,Phenothiazine,beta-carboline,Sulfur Compound
Chemical_Nomenclature : 1-[3,7-bis(dimethylamino)phenothiazin-10-yl]-3-(2-ethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)propan-1-one
Canonical SMILES : CCN1CCC2=C(C1)C3=CC=CC=C3N2CCC(=O)N4C5=C(C=C(C=C5)N(C)C)SC6=C4C=CC(=C6)N(C)C
InChI : InChI=1S\/C32H37N5OS\/c1-6-35-17-15-27-25(21-35)24-9-7-8-10-26(24)36(27)18-16-32(38)37-28-13-11-22(33(2)3)19-30(28)39-31-20-23(34(4)5)12-14-29(31)37\/h7-14,19-20H,6,15-18,21H2,1-5H3
InChIKey : ZROLWSKEMTZKCM-UHFFFAOYSA-N
Other name(s) :
MW : 539.74
Formula : C32H37N5OS
CAS_number :
PubChem : 129766372
UniChem : ZROLWSKEMTZKCM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Methylene-blue-carboline-2 ligand of proteins in family: ACHE || BCHE || Cholinesterase
Stucture :
Protein :
References (1)
| Title : Conjugates of methylene blue with gamma-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases - Bachurin_2019_Sci.Rep_9_4873 |
| Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Lushchekina SV , Rudakova EV , Dubova LG , Vinogradova DV , Sokolov VB , Aksinenko AY , Fisenko VP , Richardson RJ , Aliev G |
| Ref : Sci Rep , 9 :4873 , 2019 |
| Abstract : Bachurin_2019_Sci.Rep_9_4873 |
| ESTHER : Bachurin_2019_Sci.Rep_9_4873 |
| PubMedSearch : Bachurin_2019_Sci.Rep_9_4873 |
| PubMedID: 30890752 |