Melatonin
Melatonin is a hormone produced by the pineal gland that has multiple effects including somnolence. The secretion of melatonin increases in darkness and decreases during exposure to light and is believed to play a role in regulation of the sleep-wake cycle. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors.
General
Type : Derivative of Tryptamine,Indole,Not A\/B H target,Natural
Chemical_Nomenclature : N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
Canonical SMILES : CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
InChI : InChI=1S\/C13H16N2O2\/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13\/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChIKey : DRLFMBDRBRZALE-UHFFFAOYSA-N
Other name(s) : Melatonine,N-Acetyl-5-methoxytryptamine,Circadin,CHEBI:16796,CHEMBL45,ZINC57060,DB01065
MW : 232.28
Formula : C13H16N2O2
CAS_number : 73-31-4
PubChem : 896
UniChem : DRLFMBDRBRZALE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Melatonin ligand of proteins in family: Pectinacetylesterase-Notum
Stucture : 6TR5 Melatonin-human Notum complex
Protein : human-NOTUM
References (1)
| Title : Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum - Zhao_2019_J.Pineal.Res__e12630 |
| Author(s) : Zhao Y , Ren J , Hillier J , Jones M , Lu W , Jones EY |
| Ref : J Pineal Res , :e12630 , 2019 |
| Abstract : Zhao_2019_J.Pineal.Res__e12630 |
| ESTHER : Zhao_2019_J.Pineal.Res__e12630 |
| PubMedSearch : Zhao_2019_J.Pineal.Res__e12630 |
| PubMedID: 31876313 |
| Gene_locus related to this paper: human-NOTUM |