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Inhibitor Report for: Mahanimbine

Mahanimbine is a natural product found in Murraya euchrestifolia, Murraya siamensis. Found together with Galanthamine


General
Type Natural, Alkaloid
Chemical_Nomenclature 3,5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano[3,2-a]carbazole
Canonical SMILES CC1=CC2=C(C3=C1OC(C=C3)(C)CCC=C(C)C)NC4=CC=CC=C42
InChI InChI=1S/C23H25NO/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21/h5-6,8-11,13-14,24H,7,12H2,1-4H3
InChIKey HTNVFUBCWIYPJN-UHFFFAOYSA-N
Other name(s) (+)-Mahanimbine ; CHEBI:6646 ; Rel-(+)-Mahanimbine ; CHEMBL495873
________________________________________________________________________________________________
MW|331.4
Formula|C23H25NO
CAS_number|21104-28-9
PubChem|167963
UniChem|HTNVFUBCWIYPJN-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Mahanimbine
    Title: Mahanimbine Improved Aging-Related Memory Deficits in Mice through Enhanced Cholinergic Transmission and Suppressed Oxidative Stress, Amyloid Levels, and Neuroinflammation
    Mani V, Mohd Azahan NS, Ramasamy K, Lim SM, Abdul Majeed AB
    Ref: Brain Sci, 12:12, 2021 : PubMed

            

    Title: Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigii
    Kumar NS, Mukherjee PK, Bhadra S, Saha BP, Pal BC
    Ref: Phytother Res, 24:629, 2010 : PubMed

            

    Title: Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves
    Birari R, Roy SK, Singh A, Bhutani KK
    Ref: Nat Prod Commun, 4:1089, 2009 : PubMed