IC50 0.01 microM human-LYPLA1; IC50 0.01 microM human-ABHD11
Type : Piperidine,Triazol,tert-Butyl
Chemical_Nomenclature : (4-tert-butylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanone
Canonical SMILES : CC(C)(C)C1CCN(CC1)C(=O)N2N=CC(=N2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
InChI : InChI=1S\/C25H30N4O2\/c1-24(2,3)19-14-16-28(17-15-19)23(30)29-26-18-22(27-29)25(31,20-10-6-4-7-11-20)21-12-8-5-9-13-21\/h4-13,18-19,31H,14-17H2,1-3H3
InChIKey : LPTMHNPBMQCQPG-UHFFFAOYSA-N
Other name(s) : CHEMBL1903566,ML-211,AOB1350,BDBM50496626,ZINC72136890
MW : 418.5
Formula : C25H30N4O2
CAS_number :
PubChem : 56593118
UniChem : LPTMHNPBMQCQPG-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : ML211 ligand of proteins in family: LYsophospholipase_carboxylesterase || ABHD11-Acetyl_transferase
Stucture :
Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR |
Ref : Eur J Pharm Sci , 93 :253 , 2016 |
Abstract : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
ESTHER : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
PubMedSearch : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
PubMedID: 27544863 |
Gene_locus related to this paper: human-ABHD11 |
Title : Optimization and characterization of a triazole urea inhibitor for alpha\/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1\/LYPLA2 dual inhibitor ML211 - Adibekian_2011_Probe.Report__1 |
Author(s) : Adibekian A , Hsu KL , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
Ref : Probe Report , : , 2011 |
Abstract : Adibekian_2011_Probe.Report__1 |
ESTHER : Adibekian_2011_Probe.Report__1 |
PubMedSearch : Adibekian_2011_Probe.Report__1 |
PubMedID: 23658953 |