MC1420
Potent and reversible dual binding site AChE inhibitor
General
Type : Derivative of Donepezil,Carboxamide
Chemical_Nomenclature : (1R,3S)-3-(Benzylamino)-N-(6,7-dimethoxy-2-oxochromen-3-yl)cyclohexane-1-carboxamide
Canonical SMILES : COC1=C(C=C2C(=C1)C=C(C(=O)O2)NC(=O)C3CCCC(C3)NCC4=CC=CC=C4)OC
InChI : InChI=1S\/C25H28N2O5\/c1-30-22-13-18-12-20(25(29)32-21(18)14-23(22)31-2)27-24(28)17-9-6-10-19(11-17)26-15-16-7-4-3-5-8-16\/h3-5,7-8,12-14,17,19,26H,6,9-11,15H2,1-2H3,(H,27,28)\/t17-,19+\/m1\/s1
InChIKey : UGTGSTDFYWUXNH-MJGOQNOKSA-N
Other name(s) : N9T
MW : 436.5
Formula : C25H28N2O5
CAS_number :
PubChem : 71508421
UniChem : UGTGSTDFYWUXNH-MJGOQNOKSA-N
IUPHAR :
Wikipedia :
Target
Families : MC1420 ligand of proteins in family: ACHE
Stucture : 6TT0 Crystal structure of Torpedo californica ACHE complexed with MC1420
Protein : torca-ACHE
References (1)
| Title : Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor - Catto_2020_ACS.Med.Chem.Lett_11_869 |
| Author(s) : Catto M , Pisani L , De la Mora E , Belviso BD , Mangiatordi GF , Pinto A , Palma A , Denora N , Caliandro R , Colletier JP , Silman I , Nicolotti O , Altomare CD |
| Ref : ACS Med Chem Lett , 11 :869 , 2020 |
| Abstract : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| ESTHER : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| PubMedSearch : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| PubMedID: 32435398 |