Lycocasuarinine-D

IC50 AChE 0.22 +/-0.02 BChE 125.57 +/-7.97 microM

General

Type : Derivative of Huperzine,Natural

Chemical_Nomenclature :

Canonical SMILES : C1(NC2=C(C=C1)[C@]34[C@@H](C(C2)C=C(C3)C)C(C[N+]4([O-])C)CO)=O

InChI : InChI=1S\/C17H22N2O3\/c1-10-5-11-6-14-13(3-4-15(21)18-14)17(7-10)16(11)12(9-20)8-19(17,2)22\/h3-5,11-12,16,20H,6-9H2,1-2H3,(H,18,21)\/t11?,12?,16-,17-,19?\/m0\/s1

InChIKey : DNONHBURAUAGHR-OTZGORAJSA-N

Other name(s) : Lycocarinatumin-D,Lycocasuarinine D


MW : 302.37

Formula : C17H22N2O3

CAS_number :

PubChem :

UniChem : DNONHBURAUAGHR-OTZGORAJSA-N

IUPHAR :

Wikipedia :

Target

Families : Lycocasuarinine-D ligand of proteins in family: ACHE

Stucture :

Protein : human-ACHE

References (1)

Title : Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their cholinesterase inhibitory activities - Liu_2018_Fitoterapia_130_203
Author(s) : Liu Y , Xu PS , Ren Q , Chen X , Zhou G , Li D , Li XM , Xu KP , Yu X , Tan GS
Ref : Fitoterapia , 130 :203 , 2018
Abstract : Liu_2018_Fitoterapia_130_203
ESTHER : Liu_2018_Fitoterapia_130_203
PubMedSearch : Liu_2018_Fitoterapia_130_203
PubMedID: 30213757