LP-922056
Thienopyrimidine orally active inhibitor of NOTUM potential drug for stimulating bone formation and treating osteoporosis IC50 1.1 +/- 0.4 nM
General
Type : Pyrimidine,Sulfur Compound,Cyclopropyl
Chemical_Nomenclature : 2-(6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
Canonical SMILES : C1CC1C2=C(SC3=C2N=CN=C3SCC(=O)O)Cl
InChI : InChI=1S\/C11H9ClN2O2S2\/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16\/h4-5H,1-3H2,(H,15,16)
InChIKey : LJYRIWUQISYYHA-UHFFFAOYSA-N
Other name(s) : CHEMBL3774760,SCHEMBL439279,BDBM50154397
MW : 300.77
Formula : C11H9ClN2O2S2
CAS_number :
PubChem : 56932967
UniChem : LJYRIWUQISYYHA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : LP-922056 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture : 6T2K Furano[2,3-d]prymidine amides as human Notum inhibitors 2 (LP-922056)
Protein : human-NOTUM || mouse-notum
References (6)
| Title : Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__ |
| Author(s) : Zhao Y , Jolly S , Benvegnu S , Jones EY , Fish PV |
| Ref : Future Med Chem , : , 2021 |
| Abstract : Zhao_2021_Future.Med.Chem__ |
| ESTHER : Zhao_2021_Future.Med.Chem__ |
| PubMedSearch : Zhao_2021_Future.Med.Chem__ |
| PubMedID: 33882714 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling - Bayle_2021_J.Med.Chem__ |
| Author(s) : Bayle ED , Svensson F , Atkinson BN , Steadman D , Willis NJ , Woodward HL , Whiting P , Vincent JP , Fish PV |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : Bayle_2021_J.Med.Chem__ |
| ESTHER : Bayle_2021_J.Med.Chem__ |
| PubMedSearch : Bayle_2021_J.Med.Chem__ |
| PubMedID: 33783220 |
| Gene_locus related to this paper: human-NOTUM |
| Title : NOTUM inhibition increases endocortical bone formation and bone strength - Brommage_2019_Bone.Res_7_2 |
| Author(s) : Brommage R , Liu J , Vogel P , Mseeh F , Thompson AY , Potter DG , Shadoan MK , Hansen GM , Jeter-Jones S , Cui J , Bright D , Bardenhagen JP , Doree DD , Moverare-Skrtic S , Nilsson KH , Henning P , Lerner UH , Ohlsson C , Sands AT , Tarver JE , Powell DR , Zambrowicz B , Liu Q |
| Ref : Bone Res , 7 :2 , 2019 |
| Abstract : Brommage_2019_Bone.Res_7_2 |
| ESTHER : Brommage_2019_Bone.Res_7_2 |
| PubMedSearch : Brommage_2019_Bone.Res_7_2 |
| PubMedID: 30622831 |
| Gene_locus related to this paper: human-NOTUM |
| Title : An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent - Willis_2019_Beilstein.J.Org.Chem_15_2790 |
| Author(s) : Willis NJ , Bayle ED , Papageorgiou G , Steadman D , Atkinson BN , Mahy W , Fish PV |
| Ref : Beilstein J Org Chem , 15 :2790 , 2019 |
| Abstract : Willis_2019_Beilstein.J.Org.Chem_15_2790 |
| ESTHER : Willis_2019_Beilstein.J.Org.Chem_15_2790 |
| PubMedSearch : Willis_2019_Beilstein.J.Org.Chem_15_2790 |
| PubMedID: 31807213 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors - Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| Author(s) : Atkinson BN , Steadman D , Mahy W , Zhao Y , Sipthorp J , Bayle ED , Svensson F , Papageorgiou G , Jeganathan F , Frew S , Monaghan A , Bictash M , Jones EY , Fish PV |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126751 , 2019 |
| Abstract : Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| ESTHER : Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| PubMedSearch : Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| PubMedID: 31862412 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase - Tarver_2016_Bioorg.Med.Chem.Lett_26_1525 |
| Author(s) : Tarver JE, Jr. , Pabba PK , Barbosa J , Han Q , Gardyan MW , Brommage R , Thompson AY , Schmidt JM , Wilson AG , He W , Lombardo VK , Carson KG , Wilson AGE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :1525 , 2016 |
| Abstract : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525 |
| ESTHER : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525 |
| PubMedSearch : Tarver_2016_Bioorg.Med.Chem.Lett_26_1525 |
| PubMedID: 26897593 |
| Gene_locus related to this paper: human-NOTUM |