LIPG-inhib-Compound8i
human serum IC50, human-LIPG (endothelial) EL IC50 13 (nM), human-LIPC (hepatic) HL 5.4 (nM)
General
Type : Cyanide,Benzothiazol,Sulfur Compound,Cyclopropyl
Chemical_Nomenclature : 2-cyano-N-[2-(cyclopropylamino)-2-oxoethyl]-2-(6-phenyl-1,3-benzothiazol-2-yl)acetamide
Canonical SMILES : C1CC1NC(=O)CNC(=O)C(C#N)C2=NC3=C(S2)C=C(C=C3)C4=CC=CC=C4
InChI : InChI=1S\/C21H18N4O2S\/c22-11-16(20(27)23-12-19(26)24-15-7-8-15)21-25-17-9-6-14(10-18(17)28-21)13-4-2-1-3-5-13\/h1-6,9-10,15-16H,7-8,12H2,(H,23,27)(H,24,26)
InChIKey : SHNOGRNWVUNUKY-UHFFFAOYSA-N
Other name(s) : SCHEMBL19709502
MW : 390.5
Formula : C21H18N4O2S
CAS_number :
PubChem : 132227197
UniChem : SHNOGRNWVUNUKY-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : LIPG-inhib-Compound8i ligand of proteins in family: Lipoprotein_Lipase
Stucture :
Protein : human-LIPG
References (1)
| Title : Benzothiazole-based compounds as potent endothelial lipase inhibitors - Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| Author(s) : Meng W , Adam LP , Behnia K , Zhao L , Yang R , Kopcho LM , Locke GA , Taylor DS , Yin X , Wexler RR , Finlay H |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126673 , 2019 |
| Abstract : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| ESTHER : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| PubMedSearch : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| PubMedID: 31519373 |
| Gene_locus related to this paper: human-LIPG |