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Inhibitor Report for: KT185

General
Type Piperidine, Triazol
Chemical_Nomenclature [3-[4-[1-(2-phenylpiperidine-1-carbonyl)triazol-4-yl]phenyl]phenyl]-piperidin-1-ylmethanone
Canonical SMILES C1CCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(C=C3)C4=CN(N=N4)C(=O)N5CCCCC5C6=CC=CC=C6
InChI InChI=1S/C32H33N5O2/c38-31(35-19-6-2-7-20-35)28-13-9-12-27(22-28)24-15-17-25(18-16-24)29-23-37(34-33-29)32(39)36-21-8-5-14-30(36)26-10-3-1-4-11-26/h1,3-4,9-13,15-18,22-23,30H,2,5-8,14,19-21H2
InChIKey SGQNTNACVSWXMA-UHFFFAOYSA-N
Other name(s) KT-185 ; CHEMBL3263579 ; (2-Phenylpiperidin-1-yl)(4-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone ; BDBM50010336
________________________________________________________________________________________________
MW|519.6
Formula|C32H33N5O2
CAS_number|1472640-86-0
PubChem|53364498
UniChem|SGQNTNACVSWXMA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | KT185 ligand of proteins in family: ABHD6-Lip
Protein | human-ABHD6

References:
Search PubMed for references concerning: KT185
    Title: Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach
    Choudhary S, Malik YS, Tomar S
    Ref: Front Immunol, 11:1664, 2020 : PubMed

            

    Title: Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha/beta-hydrolase domain containing 6 (ABHD6)
    Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF
    Ref: Journal of Medicinal Chemistry, 56:8270, 2013 : PubMed