KT172
KT109 and KT172 are Specific DAGLB inhibitors. However inhibits also ABHD6 and CES1 (Iglesias 2016)
General
Type : Piperidine,Biphenyl,Triazol
Chemical_Nomenclature : (2-benzylpiperidin-1-yl)-[4-[4-(2-methoxyphenyl)phenyl]triazol-1-yl]methanone
Canonical SMILES : COC1=CC=CC=C1C2=CC=C(C=C2)C3=CN(N=N3)C(=O)N4CCCCC4CC5=CC=CC=C5
InChI : InChI=1S\/C28H28N4O2\/c1-34-27-13-6-5-12-25(27)22-14-16-23(17-15-22)26-20-32(30-29-26)28(33)31-18-8-7-11-24(31)19-21-9-3-2-4-10-21\/h2-6,9-10,12-17,20,24H,7-8,11,18-19H2,1H3
InChIKey : MXVVJNJNDCJCFS-UHFFFAOYSA-N
Other name(s) : (2-Benzylpiperidin-1-yl)(4-(2'-methoxy-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone,MLS004256809,CHEMBL2136920,SCHEMBL15427260,ML294,KT-172
MW : 452.54
Formula : C28H28N4O2
CAS_number :
PubChem : 53364485
UniChem : MXVVJNJNDCJCFS-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : KT172 ligand of proteins in family: Lipase_3 || Carb_B_Chordata || ABHD6-Lip
Stucture :
Protein :
References (4)
| Title : Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors - Iglesias_2016_J.Lipid.Res_57_131 |
| Author(s) : Iglesias J , Lamontagne J , Erb H , Gezzar S , Zhao S , Joly E , Truong VL , Skorey K , Crane S , Madiraju SR , Prentki M |
| Ref : J Lipid Res , 57 :131 , 2016 |
| Abstract : Iglesias_2016_J.Lipid.Res_57_131 |
| ESTHER : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedSearch : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedID: 26423520 |
| Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257 |
| Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013 |
| Abstract : Hsu_2013_J.Med.Chem_56_8257 |
| ESTHER : Hsu_2013_J.Med.Chem_56_8257 |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8257 |
| PubMedID: 24152245 |
| Gene_locus related to this paper: human-DAGLB |
| Title : DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses - Hsu_2012_Nat.Chem.Biol_8_999 |
| Author(s) : Hsu KL , Tsuboi K , Adibekian A , Pugh H , Masuda K , Cravatt BF |
| Ref : Nat Chemical Biology , 8 :999 , 2012 |
| Abstract : Hsu_2012_Nat.Chem.Biol_8_999 |
| ESTHER : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedSearch : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedID: 23103940 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) - Hsu_2012_Probe.Report__ |
| Author(s) : Hsu KL , Tsuboi K , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2012 |
| Abstract : Hsu_2012_Probe.Report__ |
| ESTHER : Hsu_2012_Probe.Report__ |
| PubMedSearch : Hsu_2012_Probe.Report__ |
| PubMedID: 23658950 |
| Gene_locus related to this paper: human-ABHD6 |