KC02
A negative control for KC01 the ABHD16A inhibitor IC50 > 10microM could be a relatively good inhibitor of ABHD11
General
Type : Oxooxetan
Chemical_Nomenclature : (6Z)-6-[2-oxo-4-(2-phenylethyl)oxetan-3-ylidene]hexanamide
Canonical SMILES : C1=CC=C(C=C1)CCC2C(=CCCCCC(=O)N)C(=O)O2
InChI : InChI=1S\/C17H21NO3\/c18-16(19)10-6-2-5-9-14-15(21-17(14)20)12-11-13-7-3-1-4-8-13\/h1,3-4,7-9,15H,2,5-6,10-12H2,(H2,18,19)\/b14-9-
InChIKey : XWRBNJBEHUJLPT-ZROIWOOFSA-N
Other name(s) : 6-(2-Oxo-4-phenethyloxetan-3-ylidene)hexanamide,SCHEMBL17760841,(Z)-6-(2-Oxo-4-phenethyloxetan-3-ylidene)hexanamide,6Z-[2-oxo-4-(2-phenylethyl)-3-oxetanylidene],hexanamide
MW : 287.35
Formula : C17H21NO3
CAS_number : 1646795-60-9
PubChem : 86289034
UniChem : XWRBNJBEHUJLPT-ZROIWOOFSA-N
IUPHAR :
Wikipedia :
Target
Families :
Stucture :
Protein :
References (1)
| Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164 |
| Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF |
| Ref : Nat Chemical Biology , 11 :164 , 2015 |
| Abstract : Kamat_2015_Nat.Chem.Biol_11_164 |
| ESTHER : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedID: 25580854 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a |