JZL184
Monoacylglycerol lipase (human-MGLL) selective inhibitor. Administration of JZL184 to mice was reported to cause dramatic elevation of brain 2-AG leading to several cannabinoid-related behavioral effects. Inhibits also FAAH and CES1 and a little ABHD6 Iglesias et al. Does not Inhibit Rv0183 from Mycobacterium tuberculosis (mtbMGL)
General
Type : Piperidine,Benzodioxo,FAAH inhibitor,Multitarget,pNP
Chemical_Nomenclature : (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Canonical SMILES : C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
InChI : InChI=1S\/C27H24N2O9\/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23\/h1-8,13-14,17,31H,9-12,15-16H2
InChIKey : SEGYOKHGGFKMCX-UHFFFAOYSA-N
Other name(s) : JZL 184,JZL-184,UNII-7MZ1I2J68A,CHEMBL576786
MW : 520.48
Formula : C27H24N2O9
CAS_number : 1101854-58-3
PubChem : 25021165
UniChem : SEGYOKHGGFKMCX-UHFFFAOYSA-N
IUPHAR : 5207
Wikipedia :
Target
Families : JZL184 ligand of proteins in family: Monoglyceridelipase_lysophospholip || Carb_B_Chordata || ABHD6-Lip
Stucture :
Protein : human-MGLL
References (35)
| Title : Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells - Wittig_2023_Cells_12_1757 |
| Author(s) : Wittig F , Henkel L , Pruser JL , Merkord J , Ramer R , Hinz B |
| Ref : Cells , 12 :1757 , 2023 |
| Abstract : Wittig_2023_Cells_12_1757 |
| ESTHER : Wittig_2023_Cells_12_1757 |
| PubMedSearch : Wittig_2023_Cells_12_1757 |
| PubMedID: 37443791 |
| Gene_locus related to this paper: human-MGLL |
| Title : Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function - Khara_2022_J.Exp.Biol__ |
| Author(s) : Khara LS , Amin MR , Ali DW |
| Ref : J Exp Biol , : , 2022 |
| Abstract : Khara_2022_J.Exp.Biol__ |
| ESTHER : Khara_2022_J.Exp.Biol__ |
| PubMedSearch : Khara_2022_J.Exp.Biol__ |
| PubMedID: 35438163 |
| Title : The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB(1) Cannabinoid Receptor - Pruser_2021_Mol.Cancer.Ther_20_787 |
| Author(s) : Pruser JL , Ramer R , Wittig F , Ivanov I , Merkord J , Hinz B |
| Ref : Mol Cancer Ther , 20 :787 , 2021 |
| Abstract : Pruser_2021_Mol.Cancer.Ther_20_787 |
| ESTHER : Pruser_2021_Mol.Cancer.Ther_20_787 |
| PubMedSearch : Pruser_2021_Mol.Cancer.Ther_20_787 |
| PubMedID: 33632876 |
| Gene_locus related to this paper: human-MGLL |
| Title : The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats - Demir Caltekin_2021_J.Obstet.Gynaecol.Res__ |
| Author(s) : Demir Caltekin M , Ozkut MM , Caltekin I , Kaymak E , Cakir M , Kara M , Yalvac ES |
| Ref : J Obstet Gynaecol Res , : , 2021 |
| Abstract : Demir Caltekin_2021_J.Obstet.Gynaecol.Res__ |
| ESTHER : Demir Caltekin_2021_J.Obstet.Gynaecol.Res__ |
| PubMedSearch : Demir Caltekin_2021_J.Obstet.Gynaecol.Res__ |
| PubMedID: 34008304 |
| Title : Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex - Pavon_2021_Neurobiol.Stress_14_100293 |
| Author(s) : Pavon FJ , Polis IY , Stouffer DG , Cravatt BF , Roberto M , Martin-Fardon R , Rodriguez de Fonseca F , Parsons LH , Serrano A |
| Ref : Neurobiol Stress , 14 :100293 , 2021 |
| Abstract : Pavon_2021_Neurobiol.Stress_14_100293 |
| ESTHER : Pavon_2021_Neurobiol.Stress_14_100293 |
| PubMedSearch : Pavon_2021_Neurobiol.Stress_14_100293 |
| PubMedID: 33490317 |
| Gene_locus related to this paper: human-MGLL |
| Title : The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair - Jehle_2021_Int.J.Cardiol_323_243 |
| Author(s) : Jehle J , Eich L , Danisch M , Bagheri S , Avraamidou E , Pfeifer P , Tiyerili V , Bindila L , Lutz B , Nickenig G |
| Ref : Int J Cardiol , 323 :243 , 2021 |
| Abstract : Jehle_2021_Int.J.Cardiol_323_243 |
| ESTHER : Jehle_2021_Int.J.Cardiol_323_243 |
| PubMedSearch : Jehle_2021_Int.J.Cardiol_323_243 |
| PubMedID: 32810540 |
| Title : Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice - Muldoon_2020_Neuropharmacol__108170 |
| Author(s) : Muldoon PP , Akinola LS , Schlosburg JE , Lichtman AH , Sim-Selley LJ , Mahadevan A , Cravatt BF , Damaj MI |
| Ref : Neuropharmacology , :108170 , 2020 |
| Abstract : Muldoon_2020_Neuropharmacol__108170 |
| ESTHER : Muldoon_2020_Neuropharmacol__108170 |
| PubMedSearch : Muldoon_2020_Neuropharmacol__108170 |
| PubMedID: 32479813 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress - Alteba_2020_Eur.Neuropsychopharmacol_39_70 |
| Author(s) : Alteba S , Mizrachi Zer-Aviv T , Tenenhaus A , Ben David G , Adelman J , Hillard CJ , Doron R , Akirav I |
| Ref : European Neuropsychopharmacology , 39 :70 , 2020 |
| Abstract : Alteba_2020_Eur.Neuropsychopharmacol_39_70 |
| ESTHER : Alteba_2020_Eur.Neuropsychopharmacol_39_70 |
| PubMedSearch : Alteba_2020_Eur.Neuropsychopharmacol_39_70 |
| PubMedID: 32891517 |
| Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337 |
| Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N |
| Ref : J Leukoc Biol , 106 :1337 , 2019 |
| Abstract : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| ESTHER : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| PubMedSearch : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| PubMedID: 31556464 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1 |
| Title : Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan - Chen_2019_Nat.Chem.Biol_15_453 |
| Author(s) : Chen AL , Lum KM , Lara-Gonzalez P , Ogasawara D , Cognetta AB, 3rd , To A , Parsons WH , Simon GM , Desai A , Petrascheck M , Bar-Peled L , Cravatt BF |
| Ref : Nat Chemical Biology , 15 :453 , 2019 |
| Abstract : Chen_2019_Nat.Chem.Biol_15_453 |
| ESTHER : Chen_2019_Nat.Chem.Biol_15_453 |
| PubMedSearch : Chen_2019_Nat.Chem.Biol_15_453 |
| PubMedID: 30911178 |
| Title : Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy - Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| Author(s) : Curry ZA , Wilkerson JL , Bagdas D , Kyte SL , Patel N , Donvito G , Mustafa MA , Poklis JL , Niphakis MJ , Hsu KL , Cravatt BF , Gewirtz DA , Damaj MI , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 366 :169 , 2018 |
| Abstract : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| ESTHER : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| PubMedSearch : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| PubMedID: 29540562 |
| Title : The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition - Aschauer_2018_Sci.Rep_8_8948 |
| Author(s) : Aschauer P , Zimmermann R , Breinbauer R , Pavkov-Keller T , Oberer M |
| Ref : Sci Rep , 8 :8948 , 2018 |
| Abstract : Aschauer_2018_Sci.Rep_8_8948 |
| ESTHER : Aschauer_2018_Sci.Rep_8_8948 |
| PubMedSearch : Aschauer_2018_Sci.Rep_8_8948 |
| PubMedID: 29895832 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies - O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| Author(s) : O'Hearn S , Diaz P , Wan BA , DeAngelis C , Lao N , Malek L , Chow E , Blake A |
| Ref : Ann Palliat Med , 6 :S209 , 2017 |
| Abstract : O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| ESTHER : O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| PubMedSearch : O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| PubMedID: 29156899 |
| Title : Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells - Ma_2016_Mol.Med.Rep_13_2850 |
| Author(s) : Ma M , Bai J , Ling Y , Chang W , Xie G , Li R , Wang G , Tao K |
| Ref : Mol Med Rep , 13 :2850 , 2016 |
| Abstract : Ma_2016_Mol.Med.Rep_13_2850 |
| ESTHER : Ma_2016_Mol.Med.Rep_13_2850 |
| PubMedSearch : Ma_2016_Mol.Med.Rep_13_2850 |
| PubMedID: 26847687 |
| Title : Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors - Iglesias_2016_J.Lipid.Res_57_131 |
| Author(s) : Iglesias J , Lamontagne J , Erb H , Gezzar S , Zhao S , Joly E , Truong VL , Skorey K , Crane S , Madiraju SR , Prentki M |
| Ref : J Lipid Res , 57 :131 , 2016 |
| Abstract : Iglesias_2016_J.Lipid.Res_57_131 |
| ESTHER : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedSearch : Iglesias_2016_J.Lipid.Res_57_131 |
| PubMedID: 26423520 |
| Title : Delta9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice - Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| Author(s) : Wiebelhaus JM , Grim TW , Owens RA , Lazenka MF , Sim-Selley LJ , Abdullah RA , Niphakis MJ , Vann RE , Cravatt BF , Wiley JL , Negus SS , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 352 :195 , 2015 |
| Abstract : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| ESTHER : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| PubMedSearch : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| PubMedID: 25398241 |
| Title : Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Delta9-tetrahydrocannabinol in mice - Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| Author(s) : Hruba L , Seillier A , Zaki A , Cravatt BF , Lichtman AH , Giuffrida A , McMahon LR |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 353 :261 , 2015 |
| Abstract : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| ESTHER : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| PubMedSearch : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| PubMedID: 25711338 |
| Title : Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice - Ghosh_2015_J.Pharmacol.Exp.Ther_354_111 |
| Author(s) : Ghosh S , Kinsey SG , Liu QS , Hruba L , McMahon LR , Grim TW , Merritt CR , Wise LE , Abdullah RA , Selley DE , Sim-Selley LJ , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 354 :111 , 2015 |
| Abstract : Ghosh_2015_J.Pharmacol.Exp.Ther_354_111 |
| ESTHER : Ghosh_2015_J.Pharmacol.Exp.Ther_354_111 |
| PubMedSearch : Ghosh_2015_J.Pharmacol.Exp.Ther_354_111 |
| PubMedID: 25998048 |
| Title : Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice - von Ruden_2015_Neurobiol.Dis_77_238 |
| Author(s) : von Ruden EL , Bogdanovic RM , Wotjak CT , Potschka H |
| Ref : Neurobiol Dis , 77 :238 , 2015 |
| Abstract : von Ruden_2015_Neurobiol.Dis_77_238 |
| ESTHER : von Ruden_2015_Neurobiol.Dis_77_238 |
| PubMedSearch : von Ruden_2015_Neurobiol.Dis_77_238 |
| PubMedID: 25796567 |
| Title : Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy - Ma_2014_CNS.Neurosci.Ther_20_905 |
| Author(s) : Ma L , Wang L , Yang F , Meng XD , Wu C , Ma H , Jiang W |
| Ref : CNS Neurosci Ther , 20 :905 , 2014 |
| Abstract : Ma_2014_CNS.Neurosci.Ther_20_905 |
| ESTHER : Ma_2014_CNS.Neurosci.Ther_20_905 |
| PubMedSearch : Ma_2014_CNS.Neurosci.Ther_20_905 |
| PubMedID: 24989980 |
| Title : Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model - Fernandez-Suarez_2014_Neurobiol.Aging_35_2603 |
| Author(s) : Fernandez-Suarez D , Celorrio M , Riezu-Boj JI , Ugarte A , Pacheco R , Gonzalez H , Oyarzabal J , Hillard CJ , Franco R , Aymerich MS |
| Ref : Neurobiology of Aging , 35 :2603 , 2014 |
| Abstract : Fernandez-Suarez_2014_Neurobiol.Aging_35_2603 |
| ESTHER : Fernandez-Suarez_2014_Neurobiol.Aging_35_2603 |
| PubMedSearch : Fernandez-Suarez_2014_Neurobiol.Aging_35_2603 |
| PubMedID: 24973119 |
| Title : JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy - Khasabova_2014_Pharmacol.Res_90_67 |
| Author(s) : Khasabova IA , Yao X , Paz J , Lewandowski CT , Lindberg AE , Coicou L , Burlakova N , Simone DA , Seybold VS |
| Ref : Pharmacol Res , 90 :67 , 2014 |
| Abstract : Khasabova_2014_Pharmacol.Res_90_67 |
| ESTHER : Khasabova_2014_Pharmacol.Res_90_67 |
| PubMedSearch : Khasabova_2014_Pharmacol.Res_90_67 |
| PubMedID: 25304184 |
| Title : Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome - Lysenko_2014_PLoS.One_9_e114521 |
| Author(s) : Lysenko LV , Kim J , Henry C , Tyrtyshnaia A , Kohnz RA , Madamba F , Simon GM , Kleschevnikova NE , Nomura DK , Ezekowitz RA , Kleschevnikov AM |
| Ref : PLoS ONE , 9 :e114521 , 2014 |
| Abstract : Lysenko_2014_PLoS.One_9_e114521 |
| ESTHER : Lysenko_2014_PLoS.One_9_e114521 |
| PubMedSearch : Lysenko_2014_PLoS.One_9_e114521 |
| PubMedID: 25474204 |
| Title : The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model - Ghosh_2013_Life.Sci_92_498 |
| Author(s) : Ghosh S , Wise LE , Chen Y , Gujjar R , Mahadevan A , Cravatt BF , Lichtman AH |
| Ref : Life Sciences , 92 :498 , 2013 |
| Abstract : Ghosh_2013_Life.Sci_92_498 |
| ESTHER : Ghosh_2013_Life.Sci_92_498 |
| PubMedSearch : Ghosh_2013_Life.Sci_92_498 |
| PubMedID: 22749865 |
| Gene_locus related to this paper: human-MGLL |
| Title : Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects - Kinsey_2013_J.Pharmacol.Exp.Ther_345_492 |
| Author(s) : Kinsey SG , Wise LE , Ramesh D , Abdullah R , Selley DE , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 345 :492 , 2013 |
| Abstract : Kinsey_2013_J.Pharmacol.Exp.Ther_345_492 |
| ESTHER : Kinsey_2013_J.Pharmacol.Exp.Ther_345_492 |
| PubMedSearch : Kinsey_2013_J.Pharmacol.Exp.Ther_345_492 |
| PubMedID: 23412396 |
| Gene_locus related to this paper: human-MGLL |
| Title : The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action - Kerr_2013_Br.J.Pharmacol_169_808 |
| Author(s) : Kerr D , Harhen B , Okine B , Egan L , Finn D , Roche M |
| Ref : British Journal of Pharmacology , 169 :808 , 2013 |
| Abstract : Kerr_2013_Br.J.Pharmacol_169_808 |
| ESTHER : Kerr_2013_Br.J.Pharmacol_169_808 |
| PubMedSearch : Kerr_2013_Br.J.Pharmacol_169_808 |
| PubMedID: 23043675 |
| Title : Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597 - Crow_2012_Biochem.Pharmacol_84_1215 |
| Author(s) : Crow JA , Bittles V , Borazjani A , Potter PM , Ross MK |
| Ref : Biochemical Pharmacology , 84 :1215 , 2012 |
| Abstract : Crow_2012_Biochem.Pharmacol_84_1215 |
| ESTHER : Crow_2012_Biochem.Pharmacol_84_1215 |
| PubMedSearch : Crow_2012_Biochem.Pharmacol_84_1215 |
| PubMedID: 22943979 |
| Title : Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat - Woodhams_2012_Br.J.Pharmacol_167_1609 |
| Author(s) : Woodhams S , Wong A , Barrett D , Bennett A , Chapman V , Alexander S |
| Ref : British Journal of Pharmacology , 167 :1609 , 2012 |
| Abstract : Woodhams_2012_Br.J.Pharmacol_167_1609 |
| ESTHER : Woodhams_2012_Br.J.Pharmacol_167_1609 |
| PubMedSearch : Woodhams_2012_Br.J.Pharmacol_167_1609 |
| PubMedID: 22924700 |
| Title : Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats - Sciolino_2011_Pharmacol.Res_64_226 |
| Author(s) : Sciolino NR , Zhou W , Hohmann AG |
| Ref : Pharmacol Res , 64 :226 , 2011 |
| Abstract : Sciolino_2011_Pharmacol.Res_64_226 |
| ESTHER : Sciolino_2011_Pharmacol.Res_64_226 |
| PubMedSearch : Sciolino_2011_Pharmacol.Res_64_226 |
| PubMedID: 21600985 |
| Title : Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique - Savinainen_2010_Anal.Biochem_399_132 |
| Author(s) : Savinainen JR , Yoshino M , Minkkila A , Nevalainen T , Laitinen JT |
| Ref : Analytical Biochemistry , 399 :132 , 2010 |
| Abstract : Savinainen_2010_Anal.Biochem_399_132 |
| ESTHER : Savinainen_2010_Anal.Biochem_399_132 |
| PubMedSearch : Savinainen_2010_Anal.Biochem_399_132 |
| PubMedID: 20005861 |
| Gene_locus related to this paper: human-MGLL |
| Title : Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays - Bjorklund_2010_Br.J.Pharmacol_161_1512 |
| Author(s) : Bjorklund E , Noren E , Nilsson J , Fowler CJ |
| Ref : British Journal of Pharmacology , 161 :1512 , 2010 |
| Abstract : Bjorklund_2010_Br.J.Pharmacol_161_1512 |
| ESTHER : Bjorklund_2010_Br.J.Pharmacol_161_1512 |
| PubMedSearch : Bjorklund_2010_Br.J.Pharmacol_161_1512 |
| PubMedID: 20735405 |
| Title : Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons - Straiker_2009_Mol.Pharmacol_76_1220 |
| Author(s) : Straiker A , Hu SS , Long JZ , Arnold A , Wager-Miller J , Cravatt BF , Mackie K |
| Ref : Molecular Pharmacology , 76 :1220 , 2009 |
| Abstract : Straiker_2009_Mol.Pharmacol_76_1220 |
| ESTHER : Straiker_2009_Mol.Pharmacol_76_1220 |
| PubMedSearch : Straiker_2009_Mol.Pharmacol_76_1220 |
| PubMedID: 19767452 |
| Gene_locus related to this paper: human-MGLL |
| Title : Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling - Pan_2009_J.Pharmacol.Exp.Ther_331_591 |
| Author(s) : Pan B , Wang W , Long JZ , Sun D , Hillard CJ , Cravatt BF , Liu QS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :591 , 2009 |
| Abstract : Pan_2009_J.Pharmacol.Exp.Ther_331_591 |
| ESTHER : Pan_2009_J.Pharmacol.Exp.Ther_331_591 |
| PubMedSearch : Pan_2009_J.Pharmacol.Exp.Ther_331_591 |
| PubMedID: 19666749 |
| Title : Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects - Long_2009_Nat.Chem.Biol_5_37 |
| Author(s) : Long JZ , Li W , Booker L , Burston JJ , Kinsey SG , Schlosburg JE , Pavon FJ , Serrano AM , Selley DE , Parsons LH , Lichtman AH , Cravatt BF |
| Ref : Nat Chemical Biology , 5 :37 , 2009 |
| Abstract : Long_2009_Nat.Chem.Biol_5_37 |
| ESTHER : Long_2009_Nat.Chem.Biol_5_37 |
| PubMedSearch : Long_2009_Nat.Chem.Biol_5_37 |
| PubMedID: 19029917 |
| Title : Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism - Long_2009_Chem.Biol_16_744 |
| Author(s) : Long JZ , Nomura DK , Cravatt BF |
| Ref : Chemical Biology , 16 :744 , 2009 |
| Abstract : Long_2009_Chem.Biol_16_744 |
| ESTHER : Long_2009_Chem.Biol_16_744 |
| PubMedSearch : Long_2009_Chem.Biol_16_744 |
| PubMedID: 19635411 |