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Inhibitor Report for: JMN4

JMN4 exhibited superior potency for inhibiting recombinant mouse (IC50 = 90 nM) and human (IC50 = 5.9 nM) Lp-PLA2 compared to either WWL153 (IC50 = 290 nM for mouse Lp-PLA2; IC50 = 250 nM for human Lp-PLA2) or P9 (IC50 = 470 nM for mouse Lp-PLA2; IC50 = 100 nM for human Lp-PLA2)


General
Type Piperazine, Quinoline
Chemical_Nomenclature (4-phenylphenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate
Canonical SMILES CC1=NC2=CC=CC=C2C(=C1)N3CCN(CC3)C(=O)OC4=CC=C(C=C4)C5=CC=CC=C5
InChI InChI=1S/C27H25N3O2/c1-20-19-26(24-9-5-6-10-25(24)28-20)29-15-17-30(18-16-29)27(31)32-23-13-11-22(12-14-23)21-7-3-2-4-8-21/h2-14,19H,15-18H2,1H3
InChIKey VJMDOENKGACNEX-UHFFFAOYSA-N
Other name(s) MLS003874821 ; CHEMBL2132835 ; SMR002531605 ; SR-02000001696 ; SR-02000001696-1
________________________________________________________________________________________________
MW|423.5
Formula|C27H25N3O2
CAS_number|
PubChem|53364494
UniChem|VJMDOENKGACNEX-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | JMN4 ligand of proteins in family: PAF-Acetylhydrolase
Protein | human-PLA2G7

References:
Search PubMed for references concerning: JMN4
    Title: Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)
    Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J and Cravatt BF <5 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:839, 2013 : PubMed