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JM-20

GABAergic receptor. Neuroprotective ability, anti-excitotoxic, anti-inflammatory, anti-apoptotic, mitoprotective and antioxidant effects

General

Type : Benzodiazepin,Not A\/B H target,Pyridine,Multitarget,2-nitrophenyl,Azepine

Chemical_Nomenclature : ethyl 2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine-3-carboxylate

Canonical SMILES : CCOC(=O)C1=C(NC2=C(C1C3=CC=CC=C3[N+](=O)[O-])C=NC4=CC=CC=C4N2)C

InChI : InChI=1S\/C22H20N4O4\/c1-3-30-22(27)19-13(2)24-21-15(12-23-16-9-5-6-10-17(16)25-21)20(19)14-8-4-7-11-18(14)26(28)29\/h4-12,20,24-25H,3H2,1-2H3

InChIKey : SJSJDWHYJXEJSQ-UHFFFAOYSA-N

Other name(s) : SCHEMBL16089112,3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1h-pyrido[2,3-b][1,5]benzodiazepine

MW : 404.4

Formula : C22H20N4O4

CAS_number :

PubChem : 90451879

UniChem : SJSJDWHYJXEJSQ-UHFFFAOYSA-N

Target

References (3)

Title : JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin Expression - Furtado_2021_Mol.Neurobiol_58_4615
Author(s) : Furtado ABV , Goncalves DF , Hartmann DD , Courtes AA , Cassol G , Nunez-Figueredo Y , Argolo DS , do Nascimento RP , Costa SL , da Silva VDA , Royes LFF , Soares FAA
Ref : Molecular Neurobiology , 58 :4615 , 2021
Abstract : Furtado_2021_Mol.Neurobiol_58_4615
ESTHER : Furtado_2021_Mol.Neurobiol_58_4615
PubMedSearch : Furtado_2021_Mol.Neurobiol_58_4615
PubMedID: 34148214

Title : Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources - D'Avila da Silva_2020_Biochimie_168_297
Author(s) : D'Avila da Silva F , Nogara PA , Ochoa-Rodriguez E , Nunez-Figueredo Y , Wong-Guerra M , Rosemberg DB , Rocha J
Ref : Biochimie , 168 :297 , 2020
Abstract : D'Avila da Silva_2020_Biochimie_168_297
ESTHER : D'Avila da Silva_2020_Biochimie_168_297
PubMedSearch : D'Avila da Silva_2020_Biochimie_168_297
PubMedID: 31770565

Title : Anti-hypernociceptive and anti-inflammatory effects of JM-20: A novel hybrid neuroprotective compound - Garrido-Suarez_2020_Brain.Res.Bull_165_185
Author(s) : Garrido-Suarez BB , Garrido G , Castro-Labrada M , Merino N , Valdes O , Pardo Z , Ochoa-Rodriguez E , Verdecia-Reyes Y , Delgado-Hernandez R , Godoy-Figueiredo J , Ferreira SH
Ref : Brain Research Bulletin , 165 :185 , 2020
Abstract : Garrido-Suarez_2020_Brain.Res.Bull_165_185
ESTHER : Garrido-Suarez_2020_Brain.Res.Bull_165_185
PubMedSearch : Garrido-Suarez_2020_Brain.Res.Bull_165_185
PubMedID: 33096198 
Array
(
    [id] => 987
    [inhibitor] => JM-20
    [type] => Array
        (
            [0] => Benzodiazepin
            [1] => Not A\/B H target
            [2] => Pyridine
            [3] => Multitarget
            [4] => 2-nitrophenyl
            [5] => Azepine
        )

    [other_name] => Array
        (
            [0] => SCHEMBL16089112
            [1] => 3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1h-pyrido[2,3-b][1,5]benzodiazepine
        )

    [chemical_nomenclature] => ethyl 2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine-3-carboxylate
    [formula] => C22H20N4O4
    [cas_number] => 
    [mw] => 404.4
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => D'Avila da Silva_2020_Biochimie_168_297 || Furtado_2021_Mol.Neurobiol_58_4615 || Garrido-Suarez_2020_Brain.Res.Bull_165_185
    [comment] => GABAergic receptor. Neuroprotective ability, anti-excitotoxic, anti-inflammatory, anti-apoptotic, mitoprotective and antioxidant effects
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 90451879
    [family] => 
    [inchikey] => SJSJDWHYJXEJSQ-UHFFFAOYSA-N
    [canonicalsmiles] => CCOC(=O)C1=C(NC2=C(C1C3=CC=CC=C3[N+](=O)[O-])C=NC4=CC=CC=C4N2)C
    [inchi] => InChI=1S\/C22H20N4O4\/c1-3-30-22(27)19-13(2)24-21-15(12-23-16-9-5-6-10-17(16)25-21)20(19)14-8-4-7-11-18(14)26(28)29\/h4-12,20,24-25H,3H2,1-2H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)