IC50 0.085 muM
Type : Isoquinoline
Chemical_Nomenclature : N-Isoquinolin-6-yl-2-(2-methylphenoxy)acetamide
Canonical SMILES : Cc1ccccc1OCC(=O)Nc1ccc2cnccc2c1
InChI : InChI=1S\/C18H16N2O2\/c1-13-4-2-3-5-17(13)22-12-18(21)20-16-7-6-15-11-19-9-8-14(15)10-16\/h2-11H,12H2,1H3,(H,20,21)
InChIKey : PEVCERQGPZRIFE-UHFFFAOYSA-N
Other name(s) : JV8
MW : 292.33
Formula : C18H16N2O2
CAS_number :
PubChem : 138115404
UniChem : PEVCERQGPZRIFE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Isoquinoline-45-JV8 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture : 6R8R Structure of the human Wnt deacylase Notum in complex with isoquinoline 45 JV8
Protein : human-NOTUM
Title : Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen - Atkinson_2019_Medchemcomm_10_1361 |
Author(s) : Atkinson BN , Steadman D , Zhao YG , Sipthorp J , Vecchia L , Ruza RR , Jeganathan F , Lines G , Frew S , Monaghan A , Kjaer S , Bictash M , Jones Y , Fish PV , Zhao Y , Jones EY |
Ref : Medchemcomm , 10 :1361 , 2019 |
Abstract : Atkinson_2019_Medchemcomm_10_1361 |
ESTHER : Atkinson_2019_Medchemcomm_10_1361 |
PubMedSearch : Atkinson_2019_Medchemcomm_10_1361 |
PubMedID: 31534655 |
Gene_locus related to this paper: human-NOTUM |