Indol-thioxotetrahydropyrimidine-Cpd5
IC50 AChE 0.042 and BChE 3.003 microM
General
Type : Sulfur Compound,Indole,Pyrimidine
Chemical_Nomenclature : 4-(4-Bromophenyl)-6-(1H-indol-3-yl)-2-thioxotetrahydropyrimidine-5(2H)-one
Canonical SMILES : N1C(C(C(NC1=S)C2=C[N]C3=C2C=CC=C3)=O)C4=CC=C(C=C4)Br
InChI : InChI=1S\/C18H14BrN3OS\/c19-11-7-5-10(6-8-11)15-17(23)16(22-18(24)21-15)13-9-20-14-4-2-1-3-12(13)14\/h1-9,15-16,20H,(H2,21,22,24)
InChIKey : FZQPZTBFINAZJE-UHFFFAOYSA-N
Other name(s) : Compound 5
MW : 400.29
Formula : C18H14BrN3OS
CAS_number :
PubChem :
UniChem : FZQPZTBFINAZJE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Indol-thioxotetrahydropyrimidine-Cpd5 ligand of proteins in family: ACHE
Stucture :
Protein :
References (1)
| Title : New indole derivatives as multitarget anti-Alzheimer's agents: synthesis, biological evaluation and molecular dynamics - Azmy_2023_Future.Med.Chem_15_473 |
| Author(s) : Azmy EM , Nassar IF , Hagras M , Fawzy IM , Hegazy M , Mokhtar MM , Yehia AM , Ismail NS , Lashin WH |
| Ref : Future Med Chem , 15 :473 , 2023 |
| Abstract : Azmy_2023_Future.Med.Chem_15_473 |
| ESTHER : Azmy_2023_Future.Med.Chem_15_473 |
| PubMedSearch : Azmy_2023_Future.Med.Chem_15_473 |
| PubMedID: 37125532 |