ICeD-1 and ICeD-2 (inducer of cell death-1 and 2) function by modulating DPP9 and activating the caspase recruitment domain family member 8 (CARD8) inflammasome, eliminating HIV-1 infected cells
Type : Cyanide,Pyrrolidine
Chemical_Nomenclature : 1-(2-amino-2-cyclohexylacetyl)-4-fluoropyrrolidine-2-carbonitrile
Canonical SMILES : C1CCC(CC1)C(C(=O)N2CC(CC2C#N)F)N
InChI : InChI=1S\/C13H20FN3O\/c14-10-6-11(7-15)17(8-10)13(18)12(16)9-4-2-1-3-5-9\/h9-12H,1-6,8,16H2
InChIKey : PITTXTFNBYNBSG-UHFFFAOYSA-N || PITTXTFNBYNBSG-SRVKXCTJSA-N
Other name(s) : CW8,(2S,4S)-1-((S)-2-amino-2-cyclohexylacetyl)-4-fluoropyrrolidine-2-carbonitrile
MW : 253.32
Formula : C13H20FN3O
CAS_number :
PubChem : 72617751
UniChem : PITTXTFNBYNBSG-UHFFFAOYSA-N || PITTXTFNBYNBSG-SRVKXCTJSA-N
IUPHAR :
Wikipedia :
Families : ICeD-1 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture :
Protein : human-DPP9 || human-DPP8
Title : A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells - Moore_2022_ACS.Chem.Biol_17_2595 |
Author(s) : Moore KP , Schwaid AG , Tudor M , Park S , Beshore DC , Converso A , Shipe WD , Anand R , Lan P , Moningka R , Rothman DM , Sun W , Chi A , Cornella-Taracido I , Adam GC , Bahnck-Teets C , Carroll SS , Fay JF , Goh SL , Lusen J , Quan S , Rodriguez S , Xu M , Andrews CL , Song C , Filzen T , Li J , Hollenstein K , Klein DJ , Lammens A , Lim UM , Fang Z , McHale C , Li Y , Lu M , Diamond TL , Howell BJ , Zuck P , Balibar CJ |
Ref : ACS Chemical Biology , 17 :2595 , 2022 |
Abstract : Moore_2022_ACS.Chem.Biol_17_2595 |
ESTHER : Moore_2022_ACS.Chem.Biol_17_2595 |
PubMedSearch : Moore_2022_ACS.Chem.Biol_17_2595 |
PubMedID: 36044633 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |