HyT13
Small-molecule hydrophobic used to tag and induce degradation of HaloTag fusion proteins
General
Type : Adamantyl
Chemical_Nomenclature : 2-(1-adamantyl)-N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]acetamide
Canonical SMILES : C1C2CC3CC1CC(C2)(C3)CC(=O)NCCOCCOCCCCCCCl
InChI : InChI=1S\/C22H38ClNO3\/c23-5-3-1-2-4-7-26-9-10-27-8-6-24-21(25)17-22-14-18-11-19(15-22)13-20(12-18)16-22\/h18-20H,1-17H2,(H,24,25)
InChIKey : CCDDUNSOCJMIJL-UHFFFAOYSA-N
Other name(s) : 2-((3r,5r,7r)-Adamantan-1-yl)-N-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)acetamide,2-(Adamantan-1-yl)-N-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)acetamide,SCHEMBL16146596
MW : 400.0
Formula : C22H38ClNO3
CAS_number : 1323150-58-8
PubChem : 52953446
UniChem : CCDDUNSOCJMIJL-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : HyT13 ligand of proteins in family: Haloalkane_dehalogenase-HLD2
Stucture :
Protein : rhoso-halo1
References (2)
| Title : Identification of hydrophobic tags for the degradation of stabilized proteins - Tae_2012_Chembiochem_13_538 |
| Author(s) : Tae HS , Sundberg TB , Neklesa TK , Noblin DJ , Gustafson JL , Roth AG , Raina K , Crews CM |
| Ref : Chembiochem , 13 :538 , 2012 |
| Abstract : Tae_2012_Chembiochem_13_538 |
| ESTHER : Tae_2012_Chembiochem_13_538 |
| PubMedSearch : Tae_2012_Chembiochem_13_538 |
| PubMedID: 22271667 |
| Title : Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins - Neklesa_2011_Nat.Chem.Biol_7_538 |
| Author(s) : Neklesa TK , Tae HS , Schneekloth AR , Stulberg MJ , Corson TW , Sundberg TB , Raina K , Holley SA , Crews CM |
| Ref : Nat Chemical Biology , 7 :538 , 2011 |
| Abstract : Neklesa_2011_Nat.Chem.Biol_7_538 |
| ESTHER : Neklesa_2011_Nat.Chem.Biol_7_538 |
| PubMedSearch : Neklesa_2011_Nat.Chem.Biol_7_538 |
| PubMedID: 21725302 |