fragment of huperzine which can be associated by a linker with tacrine giving (R)-Tacrine(10)-Hupyridone
Type : Derivative of Huperzine,Quinoline
Chemical_Nomenclature : 5-amino-5,6,7,8-tetrahydro-1H-quinolin-2-one
Canonical SMILES : C1CC(C2=C(C1)NC(=O)C=C2)N
InChI : InChI=1S\/C9H12N2O\/c10-7-2-1-3-8-6(7)4-5-9(12)11-8\/h4-5,7H,1-3,10H2,(H,11,12)
InChIKey : CEXVAVXEVFFVEE-UHFFFAOYSA-N
Other name(s) : 5-amino-1,2,5,6,7,8-hexahydroquinolin-2-one,Hupyridone,AC1NP21U,AC1Q53EY,5-amino-5,6,7,8-tetrahydro-1H-quinolin-2-one,SCHEMBL5941258
MW : 148.2
Formula : C9HN2O
CAS_number :
PubChem : 5148061
UniChem : CEXVAVXEVFFVEE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Title : Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease - Xuan_2021_ACS.Chem.Neurosci_12_2462 |
Author(s) : Xuan Z , Gu X , Yan S , Xie Y , Zhou Y , Zhang H , Jin H , Hu S , Mak MSH , Zhou D , Tsim KWK , Carlier PR , Han Y , Cui W |
Ref : ACS Chem Neurosci , 12 :2462 , 2021 |
Abstract : Xuan_2021_ACS.Chem.Neurosci_12_2462 |
ESTHER : Xuan_2021_ACS.Chem.Neurosci_12_2462 |
PubMedSearch : Xuan_2021_ACS.Chem.Neurosci_12_2462 |
PubMedID: 34156230 |
Title : Promising tacrine\/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget - Mak_2021_J.Neurochem__ |
Author(s) : Mak S , Li W , Fu H , Luo J , Cui W , Hu S , Pang Y , Carlier PR , Tsim KWK , Pi R , Han Y |
Ref : Journal of Neurochemistry , : , 2021 |
Abstract : Mak_2021_J.Neurochem__ |
ESTHER : Mak_2021_J.Neurochem__ |
PubMedSearch : Mak_2021_J.Neurochem__ |
PubMedID: 33930191 |
Title : Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice - Chen_2018_Front.Cell.Neurosci_12_396 |
Author(s) : Chen H , Wu X , Gu X , Zhou Y , Ye L , Zhang K , Pan H , Wang J , Wei H , Zhu B , Naman CB , Mak SH , Carlier PR , Cui W , Han YF |
Ref : Front Cell Neurosci , 12 :396 , 2018 |
Abstract : Chen_2018_Front.Cell.Neurosci_12_396 |
ESTHER : Chen_2018_Front.Cell.Neurosci_12_396 |
PubMedSearch : Chen_2018_Front.Cell.Neurosci_12_396 |
PubMedID: 30483056 |
Title : Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice - Chen_2018_Metab.Brain.Dis_33_1131 |
Author(s) : Chen H , Xiang S , Huang L , Lin J , Hu S , Mak SH , Wang C , Wang Q , Cui W , Han Y |
Ref : Metabolic Brain Disease , 33 :1131 , 2018 |
Abstract : Chen_2018_Metab.Brain.Dis_33_1131 |
ESTHER : Chen_2018_Metab.Brain.Dis_33_1131 |
PubMedSearch : Chen_2018_Metab.Brain.Dis_33_1131 |
PubMedID: 29564727 |
Title : Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease - Fink_1995_J.Med.Chem_38_3645 |
Author(s) : Fink DM , Bores GM , Effland RC , Huger FP , Kurys BE , Rush DK , Selk DE |
Ref : Journal of Medicinal Chemistry , 38 :3645 , 1995 |
Abstract : Fink_1995_J.Med.Chem_38_3645 |
ESTHER : Fink_1995_J.Med.Chem_38_3645 |
PubMedSearch : Fink_1995_J.Med.Chem_38_3645 |
PubMedID: 7658452 |