HALSTS-1Q9
Compound close to HALSTS1 (Neklesa et al.) N-(3,5-dichloro-2-ethoxybenzyl)-2H-tetrazol-5-amine as a nanomolar HALoTag2 Stabilizer (HALTS1) that reduces the Hsp70:HaloTag2 interaction, thereby preventing HaloTag2 ubiquitination here di methyl instead of dichloro
General
Type : HaloTag-ligand,Tetrazol
Chemical_Nomenclature : N-[(2-ethoxy-3,5-dimethylphenyl)methyl]-2H-tetrazol-5-amine
Canonical SMILES : CCOC1=C(C=C(C=C1CNC2=NNN=N2)C)C
InChI : InChI=1S\/C12H17N5O\/c1-4-18-11-9(3)5-8(2)6-10(11)7-13-12-14-16-17-15-12\/h5-6H,4,7H2,1-3H3,(H2,13,14,15,16,17)
InChIKey : WHEQZFWVEMEFGH-UHFFFAOYSA-N
Other name(s) : 1Q9
MW : 247.30
Formula : C12H17N5O
CAS_number :
PubChem : 71464720
UniChem : WHEQZFWVEMEFGH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : HALSTS-1Q9 ligand of proteins in family: Haloalkane_dehalogenase-HLD2
Stucture :
Protein : rhoso-halo1
References (1)
| Title : A bidirectional system for the dynamic small molecule control of intracellular fusion proteins - Neklesa_2013_ACS.Chem.Biol_8_2293 |
| Author(s) : Neklesa TK , Noblin DJ , Kuzin AP , Lew S , Seetharaman J , Acton TB , Kornhaber GJ , Xiao R , Montelione GT , Tong L , Crews CM |
| Ref : ACS Chemical Biology , 8 :2293 , 2013 |
| Abstract : Neklesa_2013_ACS.Chem.Biol_8_2293 |
| ESTHER : Neklesa_2013_ACS.Chem.Biol_8_2293 |
| PubMedSearch : Neklesa_2013_ACS.Chem.Biol_8_2293 |
| PubMedID: 23978068 |
| Gene_locus related to this paper: rhoso-halo1 |