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H-Lys(4-nitro-Z)-pyrrolidide

non-selective DP4 inhibitor. Ki toward DPP4: 84 nM

General

Type : Pyrrolidine,Carbamate,pNP,Peptide

Chemical_Nomenclature : (4-nitrophenyl)methyl N-(5-amino-6-oxo-6-pyrrolidin-1-ylhexyl)carbamate || (4-nitrophenyl)methyl N-[(5S)-5-amino-6-oxo-6-pyrrolidin-1-ylhexyl]carbamate

Canonical SMILES : C1CCN(C1)C(=O)C(CCCCNC(=O)OCC2=CC=C(C=C2)[N+](=O)[O-])N

InChI : InChI=1S\/C18H26N4O5\/c19-16(17(23)21-11-3-4-12-21)5-1-2-10-20-18(24)27-13-14-6-8-15(9-7-14)22(25)26\/h6-9,16H,1-5,10-13,19H2,(H,20,24) || InChI=1S\/C18H26N4O5\/c19-16(17(23)21-11-3-4-12-21)5-1-2-10-20-18(24)27-13-14-6-8-15(9-7-14)22(25)26\/h6-9,16H,1-5,10-13,19H2,(H,20,24)\/t16-\/m0\/s1

InChIKey : YDYSCRZHYWLSPQ-UHFFFAOYSA-N || YDYSCRZHYWLSPQ-INIZCTEOSA-N

Other name(s) : H-Lys(4-nitro-Z)-pyrrolidide HCl,HMS3749I21,Lys-(4-nitro-Z)-pyrrolidide,Lys[Z(NO2)]-pyrrolidide,LZNP,DPP-IV-IN-2,h-lys[z(4-no2)]-pyrrolidide,H-Lys(4-nitro-Z)-pyrrolidide . HCl,CHEMBL505629,ZINC8076607

MW : 378.4

Formula : C18H26N4O5

CAS_number : 136259-18-2

PubChem : 84951961, 9209502

UniChem : YDYSCRZHYWLSPQ-UHFFFAOYSA-N || YDYSCRZHYWLSPQ-INIZCTEOSA-N

IUPHAR :

Wikipedia :

Target

Families : H-Lys(4-nitro-Z)-pyrrolidide ligand of proteins in family: DPP4N_Peptidase_S9

Stucture :

Protein : human-DPP4

References (1)

Title : Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects - Bank_2011_Biol.Chem_392_169
Author(s) : Bank U , Heimburg A , Wohlfarth A , Koch G , Nordhoff K , Julius H , Helmuth M , Breyer D , Reinhold D , Tager M , Ansorge S
Ref : Biol Chem , 392 :169 , 2011
Abstract : Bank_2011_Biol.Chem_392_169
ESTHER : Bank_2011_Biol.Chem_392_169
PubMedSearch : Bank_2011_Biol.Chem_392_169
PubMedID: 21194378