Goodyera schlechtendaliana Reichb.f., a member of the genus Goodyera, is an orchidaceous edible medicinal plant of China. Goodyschle-A BChE inhibitory activity (IC50 value 6.88 +/- 1.63 muM
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Title: Goodyschle A, a new butenolide with significant BchE inhibitory activity from Goodyera schlechtendaliana Dai LY, Yin QM, Qiu JK, Zhang ZY, Li G, Huang MN, Liu L Ref: Nat Prod Res, :1, 2020 : PubMed
Goodyschle A (1), a new butenolide, was isolated from the whole grass of Goodyera schlechtendaliana, an orchidaceous edible medicinal plant. The structure of the new compound was elucidated by 1 D and 2 D NMR experiments in addition to HRESIMS analyses. Compound 1 was evaluated for its bioactivities including cytotoxic activity against human gastric cancer (SGC-7901) and human hepatocellular carcinoma (HepG2) cell lines, inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and DPPH radical scavenging activity. As a result, compound 1 showed potent BChE inhibitory activity (IC50 value = 6.88 +/- 1.63 muM), moderate DPPH radical scavenging activity (IC50 value = 16.25 +/- 0.21 muM), and slight AChE inhibitory and cytotoxic activities. These findings suggest that compound 1 is worthy for further investigations in terms of its selective BChE inhibitory activity.
