Fotagliptin
General
Type : Gliptin,Cyanide,Piperidine,Triazine
Chemical_Nomenclature : 2-[[3-[(3R)-3-aminopiperidin-1-yl]-6-methyl-5-oxo-1,2,4-triazin-4-yl]methyl]-4-fluorobenzonitrile
Canonical SMILES : CC1=NN=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N
InChI : InChI=1S\/C17H19FN6O\/c1-11-16(25)24(9-13-7-14(18)5-4-12(13)8-19)17(22-21-11)23-6-2-3-15(20)10-23\/h4-5,7,15H,2-3,6,9-10,20H2,1H3\/t15-\/m1\/s1
InChIKey : IXSWMXRAIPXMRH-OAHLLOKOSA-N
Other name(s) : SCHEMBL2020371,IXSWMXRAIPXMRH-OAHLLOKOSA-N,AKOS040748376
MW : 342.4
Formula : C17H19FN6O
CAS_number : 1312954-58-7
PubChem : 53258570
UniChem : IXSWMXRAIPXMRH-OAHLLOKOSA-N
IUPHAR :
Wikipedia :
Target
Families : Fotagliptin ligand of proteins in family: DPP4N_Peptidase_S9
Stucture :
Protein : human-DPP4
References (2)
| Title : Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial - Xu_2023_BMC.Med_21_388 |
| Author(s) : Xu M , Sun K , Xu W , Wang C , Yan D , Li S , Cong L , Pi Y , Song W , Sun Q , Xiao R , Peng W , Wang J , Peng H , Zhang Y , Duan P , Zhang M , Liu J , Huang Q , Li X , Bao Y , Zeng T , Wang K , Qin L , Wu C , Deng C , Huang C , Yan S , Zhang W , Li M , Sun L , Wang Y , Li H , Wang G , Pang S , Zheng X , Wang H , Wang F , Su X , Ma Y , Li Z , Xie Z , Xu N , Ni L , Zhang L , Deng X , Pan T , Dong Q , Wu X , Shen X , Zhang X , Zou Q , Jiang C , Xi J , Ma J , Sun J , Yan L |
| Ref : BMC Med , 21 :388 , 2023 |
| Abstract : Xu_2023_BMC.Med_21_388 |
| ESTHER : Xu_2023_BMC.Med_21_388 |
| PubMedSearch : Xu_2023_BMC.Med_21_388 |
| PubMedID: 37814306 |
| Title : Safety and pharmacokinetic interaction between fotagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin in healthy subjects - Ding_2021_Expert.Opin.Drug.Metab.Toxicol_17_725 |
| Author(s) : Ding Y , Zhang H , Li C , Zheng W , Wang M , Li Y , Sun H , Wu M |
| Ref : Expert Opin Drug Metab Toxicol , 17 :725 , 2021 |
| Abstract : Ding_2021_Expert.Opin.Drug.Metab.Toxicol_17_725 |
| ESTHER : Ding_2021_Expert.Opin.Drug.Metab.Toxicol_17_725 |
| PubMedSearch : Ding_2021_Expert.Opin.Drug.Metab.Toxicol_17_725 |
| PubMedID: 33899649 |