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Inhibitor Report for: Fasciculin2

Peptide of 61 residues isolated from Dendroaspis angusticeps (green mamba) venom. Potent inhibitor of some vertebrates AChE. More info FAS pages(HTML) and webace P0C1Z0 3SE2_DENAN dans uniprot


General
Type Fasciculin2 variant, Natural_modified, Natural, Peptide, Sulfur Compound
Chemical_Nomenclature TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
Canonical SMILES CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CS)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)N4CCCC4C(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CS)C(=O)NCC(=O)NC(CS)C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)N7CCCC7C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)C(CC9=CN=CN9)NC(=O)C(CO)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CS)NC(=O)C(CCSC)NC(=O)C(C(C)O)N
InChI InChI=1S/C276H446N88O90S10/c1-22-131(12)210(354-216(398)132(13)310-221(403)152(46-32-78-299-273(288)289)320-246(428)178(114-368)344-262(444)213(136(17)373)358-265(447)215(138(19)375)359-264(446)214(137(18)374)356-244(426)165(95-142-104-296-124-308-142)330-247(429)176(112-366)342-235(417)164(93-140-57-63-145(377)64-58-140)329-249(431)182(118-457)349-230(412)158(71-87-463-20)325-257(439)207(285)133(14)370)260(442)337-162(91-128(6)7)243(425)355-211(134(15)371)261(443)338-169(100-196(284)382)239(421)346-181(117-456)220(402)306-107-198(384)312-156(67-69-202(388)389)229(411)331-168(99-195(283)381)238(420)343-177(113-367)248(430)350-184(120-459)250(432)328-163(92-139-55-61-144(376)62-56-139)234(416)319-153(47-33-79-300-274(290)291)223(405)316-148(41-23-27-73-277)226(408)341-175(111-365)245(427)321-154(48-34-80-301-275(292)293)224(406)317-155(49-35-81-302-276(294)295)225(407)339-173(96-143-105-297-125-309-143)266(448)363-85-39-53-191(363)270(452)362-84-38-52-190(362)255(437)324-150(43-25-29-75-279)222(404)323-159(72-88-464-21)232(414)353-209(130(10)11)259(441)336-160(89-126(2)3)218(400)304-106-197(383)311-147(45-31-77-298-272(286)287)217(399)303-108-200(386)314-180(116-455)219(401)305-109-201(387)315-187(123-462)268(450)364-86-40-54-192(364)269(451)361-83-36-50-188(361)254(436)307-110-199(385)313-170(101-204(392)393)240(422)334-171(102-205(394)395)242(424)332-166(97-193(281)379)236(418)327-161(90-127(4)5)233(415)322-157(68-70-203(390)391)231(413)352-208(129(8)9)258(440)326-151(44-26-30-76-280)228(410)348-185(121-460)252(434)351-186(122-461)253(435)357-212(135(16)372)263(445)345-179(115-369)267(449)360-82-37-51-189(360)256(438)335-172(103-206(396)397)241(423)318-149(42-24-28-74-278)227(409)347-183(119-458)251(433)333-167(98-194(282)380)237(419)340-174(271(453)454)94-141-59-65-146(378)66-60-141/h55-66,104-105,124-138,147-192,207-215,365-378,455-462H,22-54,67-103,106-123,277-280,285H2,1-21H3,(H2,281,379)(H2,282,380)(H2,283,381)(H2,284,382)(H,296,308)(H,297,309)(H,303,399)(H,304,400)(H,305,401)(H,306,402)(H,307,436)(H,310,403)(H,311,383)(H,312,384)(H,313,385)(H,314,386)(H,315,387)(H,316,405)(H,317,406)(H,318,423)(H,319,416)(H,320,428)(H,321,427)(H,322,415)(H,323,404)(H,324,437)(H,325,439)(H,326,440)(H,327,418)(H,328,432)(H,329,431)(H,330,429)(H,331,411)(H,332,424)(H,333,433)(H,334,422)(H,335,438)(H,336,441)(H,337,442)(H,338,443)(H,339,407)(H,340,419)(H,341,408)(H,342,417)(H,343,420)(H,344,444)(H,345,445)(H,346,421)(H,347,409)(H,348,410)(H,349,412)(H,350,430)(H,351,434)(H,352,413)(H,353,414)(H,354,398)(H,355,425)(H,356,426)(H,357,435)(H,358,447)(H,359,446)(H,388,389)(H,390,391)(H,392,393)(H,394,395)(H,396,397)(H,453,454)(H4,286,287,298)(H4,288,289,299)(H4,290,291,300)(H4,292,293,301)(H4,294,295,302)/t131-,132-,133+,134+,135+,136+,137+,138+,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,191-,192-,207-,208-,209-,210-,211-,212-,213-,214-,215-/m0/s1
InChIKey MJJAZTXUQMIMKK-VYTSXJHUSA-N
Other name(s) Toxin F7 ; Eastern green mamba venom toxin F(7) ; Toxin F(sub 7) (Dendroaspis angusticeps reduced) ; Toxin F(sub VII) (Dendroaspis angusticeps reduced)
________________________________________________________________________________________________
MW|7 kD
Formula|C276H446N88O90S10
CAS_number|50863-84-8
PubChem|123131949
UniChem|MJJAZTXUQMIMKK-VYTSXJHUSA-N
IUPHAR|
Wikipedia|

Target
Families | Fasciculin2 ligand of proteins in family: ACHE
Stucture | 9 structures (e.g. : 1FSC, 1FSS, 1MAH... more)
Protein | mouse-ACHE, human-ACHE

References:
Search PubMed for references concerning: Fasciculin2

46 more
    Title: Acetylcholinesterases from Elapidae snake venoms: biochemical, immunological and enzymatic characterization
    Frobert Y, Creminon C, Cousin X, Remy MH, Chatel JM, Bon S, Bon C, Grassi J
    Ref: Biochimica & Biophysica Acta, 1339:253, 1997 : PubMed

            

    Title: Cloning and expression of acetylcholinesterase from Bungarus fasciatus venom. A new type of cooh-terminal domain; involvement of a positively charged residue in the peripheral site
    Cousin X, Bon S, Duval N, Massoulie J, Bon C
    Ref: Journal of Biological Chemistry, 271:15099, 1996 : PubMed

            

    Title: Site of fasciculin interaction with acetylcholinesterase
    Radic Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P
    Ref: Journal of Biological Chemistry, 269:11233, 1994 : PubMed