VX analogue. Fluorogenic organophosphate diesters that produce fluorescence emission upon hydrolysis.The first ester is ethyl (E), isopropyl (I), cyclohexyl (C) or pinacoyl (P) analogous to the structure of VX, Sarin, Cyclosarin, and Somen respectively. The fluorescent ester is 3-cyano-4-methyl-7-hydroxy coumarin (MeCyC) or 1,3-dichloro-7-hydroxy-9,9-dimethyl-9H-acridin-2-one (DDAO)
Type : Organophosphate,Flu-OP,Nerve Agent V-series,Surrogate OP,Derivative of Tacrine
Chemical_Nomenclature : methylphosphonic acid ethyl ester 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydro-acridin-2-yl
Canonical SMILES : CCO[P](=O)(C)OC1=CC3=C(C=C1)N=C2C=C(C(=O)C(=C2C3(C)C)Cl)Cl
InChI : InChI=1S\/C18H18Cl2NO4P\/c1-5-24-26(4,23)25-10-6-7-13-11(8-10)18(2,3)15-14(21-13)9-12(19)17(22)16(15)20\/h6-9H,5H2,1-4H3
InChIKey : ULLJVTHIBSXGQA-UHFFFAOYSA-N
Other name(s) :
MW : 414.22
Formula : C18H18Cl2NO4P
CAS_number :
PubChem :
UniChem : ULLJVTHIBSXGQA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Title : Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity - Amitai_2007_Toxicology_233_187 |
Author(s) : Amitai G , Adani R , Yacov G , Yishay S , Teitlboim S , Tveria L , Limanovich O , Kushnir M , Meshulam H |
Ref : Toxicology , 233 :187 , 2007 |
Abstract : Amitai_2007_Toxicology_233_187 |
ESTHER : Amitai_2007_Toxicology_233_187 |
PubMedSearch : Amitai_2007_Toxicology_233_187 |
PubMedID: 17129656 |
Title : Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase - Amitai_2006_FEBS.J_273_1906 |
Author(s) : Amitai G , Gaidukov L , Adani R , Yishay S , Yacov G , Kushnir M , Teitlboim S , Lindenbaum M , Bel P , Khersonsky O , Tawfik DS , Meshulam H |
Ref : Febs J , 273 :1906 , 2006 |
Abstract : Amitai_2006_FEBS.J_273_1906 |
ESTHER : Amitai_2006_FEBS.J_273_1906 |
PubMedSearch : Amitai_2006_FEBS.J_273_1906 |
PubMedID: 16640555 |