Donepezil-derivative-DZ7
non-chiral donepezil-like inhibitor 17 compound 1 in the publication
General
Type : Piperidine,Derivative of Donepezil,Inden
Chemical_Nomenclature : (2~{E})-5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methylidene]-3~{H}-inden-1-one
Canonical SMILES : COc1cc2CC(=C\/C3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
InChI : 1S\/C24H27NO3\/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18\/h3-7,12,14-15,17H,8-11,13,16H2,1-2H3\/b20-12+
InChIKey : LPMOTUSFDTTWJL-UDWIEESQSA-N
Other name(s) :
MW : 377.48
Formula : C24H27NO3
CAS_number :
PubChem : 10762160
UniChem : LPMOTUSFDTTWJL-UDWIEESQSA-N
IUPHAR :
Wikipedia :
Target
Families : Donepezil-derivative-DZ7 ligand of proteins in family: ACHE
Stucture : 5NAP Torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like inhibitor 17
Protein : torca-ACHE
References (1)
| Title : Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues - Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| Author(s) : Caliandro R , Pesaresi A , Cariati L , Procopio A , Oliverio M , Lamba D |
| Ref : J Enzyme Inhib Med Chem , 33 :794 , 2018 |
| Abstract : Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| ESTHER : Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| PubMedSearch : Caliandro_2018_J.Enzyme.Inhib.Med.Chem_33_794 |
| PubMedID: 29651884 |
| Gene_locus related to this paper: torca-ACHE |