Dihomo-gamma-linolenic-acid
Dihomo-gamma-linolenic acid (DGLA) is a precursor of physiologically active eicosanoids, including group 1 prostaglandins and thromboxanes. DGLA is used in combination with interferons for the enhancement of the anti-virus, anti-cancer, or anti-inflammatory effects, and in combination with prostaglandin E1 for the treatment of atopy of the skin and mucosa. For nutritional supplementation, also for treating dietary shortage or imbalance. The role of FASN inhibition is unknown. Dihomo-gamma-linolenic acid is a 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.
General
Type : Fatty acid
Chemical_Nomenclature : (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
Canonical SMILES : CCCCCC=CCC=CCC=CCCCCCCC(=O)O
InChI : InChI=1S\/C20H34O2\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22\/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)\/b7-6-,10-9-,13-12-
InChIKey : HOBAELRKJCKHQD-QNEBEIHSSA-N
Other name(s) : Dihomo-gamma-linolenic acid,DGLA,Gamma-Homolinolenic acid,Homo-gamma-linolenic acid,8,11,14-Eicosatrienoic acid,Cis-8,11,14-Eicosatrienoic Acid
MW : 306.48
Formula : C20H34O2
CAS_number : 1783-84-2
PubChem : 5280581
UniChem : HOBAELRKJCKHQD-QNEBEIHSSA-N
IUPHAR :
Wikipedia :
Target
Families : Dihomo-gamma-linolenic-acid ligand of proteins in family: Thioesterase
Stucture :
Protein : human-FASN
References (1)
| Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA |
| Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011 |
| Abstract : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| ESTHER : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedSearch : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedID: 21908709 |
| Gene_locus related to this paper: human-FASN |