DMSO
DMSO is an organosulfur compound, colorless liquid used as an an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. Used as a cryoprotectant. It penetrate the skin and other membranes without damaging them and could carry other compounds into a biological system
General
Type : Sulfur Compound
Chemical_Nomenclature : methylsulfinylmethane
Canonical SMILES : CS(=O)C
InChI : InChI=1S\/C2H6OS\/c1-4(2)3\/h1-2H3
InChIKey : IAZDPXIOMUYVGZ-UHFFFAOYSA-N
Other name(s) : Dimethyl sulfoxide,Methyl sulfoxide,Methylsulfinylmethane,Dimethyl sulphoxide
MW : 78.12
Formula : C2H6OS
CAS_number : 67-68-5
PubChem : 679
UniChem : IAZDPXIOMUYVGZ-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Dimethyl_sulfoxide
Target
Families : DMSO ligand of proteins in family: AlphaBeta_hydrolase
Stucture : 3WWD The complex of pOPH_S172A with DMSO(Pseudomonas sp. Oxidized polyvinyl alcohol hydrolase (OPH))
Protein : psesp-OPH
References (10)
| Title : DMSO: A Mixed-Competitive Inhibitor of Human Acetylcholinesterase - Kumar_2017_ACS.Chem.Neurosci_8_2618 |
| Author(s) : Kumar A , Darreh-Shori T |
| Ref : ACS Chem Neurosci , 8 :2618 , 2017 |
| Abstract : Kumar_2017_ACS.Chem.Neurosci_8_2618 |
| ESTHER : Kumar_2017_ACS.Chem.Neurosci_8_2618 |
| PubMedSearch : Kumar_2017_ACS.Chem.Neurosci_8_2618 |
| PubMedID: 29017007 |
| Title : Roles of tryptophan residue and disulfide bond in the variable lid region of oxidized polyvinyl alcohol hydrolase - Yang_2014_Biochem.Biophys.Res.Commun_452_509 |
| Author(s) : Yang Y , Ko TP , Liu L , Li J , Huang CH , Chen J , Guo RT , Du G |
| Ref : Biochemical & Biophysical Research Communications , 452 :509 , 2014 |
| Abstract : Yang_2014_Biochem.Biophys.Res.Commun_452_509 |
| ESTHER : Yang_2014_Biochem.Biophys.Res.Commun_452_509 |
| PubMedSearch : Yang_2014_Biochem.Biophys.Res.Commun_452_509 |
| PubMedID: 25173935 |
| Gene_locus related to this paper: sphs1-OPH |
| Title : Engineering the loops in a lipase for stability in DMSO - Yedavalli_2013_Protein.Eng.Des.Sel_26_317 |
| Author(s) : Yedavalli P , Rao NM |
| Ref : Protein Engineering Des Sel , 26 :317 , 2013 |
| Abstract : Yedavalli_2013_Protein.Eng.Des.Sel_26_317 |
| ESTHER : Yedavalli_2013_Protein.Eng.Des.Sel_26_317 |
| PubMedSearch : Yedavalli_2013_Protein.Eng.Des.Sel_26_317 |
| PubMedID: 23404771 |
| Title : Effects per se of organic solvents in the cerebral acetylcholinesterase of rats - Obregon_2005_Neurochem.Res_30_379 |
| Author(s) : Obregon AD , Schetinger MR , Correa MM , Morsch VM , da Silva JE , Martins MA , Bonacorso HG , Zanatta N |
| Ref : Neurochem Res , 30 :379 , 2005 |
| Abstract : Obregon_2005_Neurochem.Res_30_379 |
| ESTHER : Obregon_2005_Neurochem.Res_30_379 |
| PubMedSearch : Obregon_2005_Neurochem.Res_30_379 |
| PubMedID: 16018582 |
| Title : Different regulatory patterns of M1 and M2 muscarinic receptor subtype RNA in SH-SY5Y human neuroblastoma induced by phorbol ester or DMSO - Koman_1993_Neurosci.Lett_149_79 |
| Author(s) : Koman A , Cazaubon S , Adem A , Couraud PO , Strosberg AD |
| Ref : Neuroscience Letters , 149 :79 , 1993 |
| Abstract : Koman_1993_Neurosci.Lett_149_79 |
| ESTHER : Koman_1993_Neurosci.Lett_149_79 |
| PubMedSearch : Koman_1993_Neurosci.Lett_149_79 |
| PubMedID: 7682303 |
| Title : Postsynaptic effects of DMSO at the frog neuromuscular junction - Cherki-Vakil_1991_Brain.Res_566_329 |
| Author(s) : Cherki-Vakil R , Meiri H |
| Ref : Brain Research , 566 :329 , 1991 |
| Abstract : Cherki-Vakil_1991_Brain.Res_566_329 |
| ESTHER : Cherki-Vakil_1991_Brain.Res_566_329 |
| PubMedSearch : Cherki-Vakil_1991_Brain.Res_566_329 |
| PubMedID: 1814550 |
| Title : The actions of dimethyl sulfoxide on neuromuscular transmission - McLarnon_1986_Mol.Pharmacol_30_631 |
| Author(s) : McLarnon JG , Saint DA , Quastel DM |
| Ref : Molecular Pharmacology , 30 :631 , 1986 |
| Abstract : McLarnon_1986_Mol.Pharmacol_30_631 |
| ESTHER : McLarnon_1986_Mol.Pharmacol_30_631 |
| PubMedSearch : McLarnon_1986_Mol.Pharmacol_30_631 |
| PubMedID: 3785140 |
| Title : Dimethyl sulfoxide: inhibition of acetylcholinesterase in the mammalian heart - Watts_1984_Biochem.Pharmacol_33_365 |
| Author(s) : Watts JA , Hoogmoed RP |
| Ref : Biochemical Pharmacology , 33 :365 , 1984 |
| Abstract : Watts_1984_Biochem.Pharmacol_33_365 |
| ESTHER : Watts_1984_Biochem.Pharmacol_33_365 |
| PubMedSearch : Watts_1984_Biochem.Pharmacol_33_365 |
| PubMedID: 6704158 |
| Title : Competitive inhibition by dimethylsulfoxide of molluscan and vertebrate acetylcholinesterase - Plummer_1983_Biochem.Pharmacol_32_151 |
| Author(s) : Plummer JM , Greenberg MJ , Lehman HK , Watts JA |
| Ref : Biochemical Pharmacology , 32 :151 , 1983 |
| Abstract : Plummer_1983_Biochem.Pharmacol_32_151 |
| ESTHER : Plummer_1983_Biochem.Pharmacol_32_151 |
| PubMedSearch : Plummer_1983_Biochem.Pharmacol_32_151 |
| PubMedID: 6830611 |
| Title : Cardiac chronotropic mechanisms of dimethyl sulphoxide: inhibition of acetylcholinesterase and antagonism of negative chronotropy by atropine - Shlafer_1976_Arch.Int.Pharmacodyn.Ther_221_21 |
| Author(s) : Shlafer M , Matheny JL , Karow AM, Jr. |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 221 :21 , 1976 |
| Abstract : Shlafer_1976_Arch.Int.Pharmacodyn.Ther_221_21 |
| ESTHER : Shlafer_1976_Arch.Int.Pharmacodyn.Ther_221_21 |
| PubMedSearch : Shlafer_1976_Arch.Int.Pharmacodyn.Ther_221_21 |
| PubMedID: 962427 |