1. Home
  2. Inhibitor
  3. Cpd17-Tacrine-5-HT6

Cpd17-Tacrine-5-HT6

reversible inhibitor of acetyl- and butyrylcholinesterase (IC50 = 8 nM and IC50 = 24 nM respectively). Inhibit aggregation of amyloid-beta in vitro 75% at 10 microM. 5-HT6R antagonist Ki 13 nM

General

Type : Acridine,Derivative of Tacrine,Multitarget,5-HT-receptor-ligand,Sulfur Compound,Sulfonamide,Indole,Alkyl linked bis-ligand,anti-Abeta-aggregation

Chemical_Nomenclature : N1-(2-((1-(phenylsulfonyl)-1H-indol-4-yl)oxy)ethyl)-N2-(1,2,3,4-tetrahydroacridin-9-yl)ethane-1,2-diamine

Canonical SMILES : C1(=CC=CC2=C1C=C[N]2[S](=O)(=O)C3=CC=CC=C3)OCCNCCNC4=C6C(=NC5=CC=CC=C45)CCCC6

InChI : InChI=1S\/C31H32N4O3S\/c36-39(37,23-9-2-1-3-10-23)35-21-17-26-29(35)15-8-16-30(26)38-22-20-32-18-19-33-31-24-11-4-6-13-27(24)34-28-14-7-5-12-25(28)31\/h1-4,6,8-11,13,15-17,21,32H,5,7,12,14,18-20,22H2,(H,33,34)

InChIKey : ZJGZDAGZMPYZKM-UHFFFAOYSA-N

Other name(s) :

MW : 540.67

Formula : C31H32N4O3S

CAS_number :

PubChem :

UniChem : ZJGZDAGZMPYZKM-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : Cpd17-Tacrine-5-HT6 ligand of proteins in family: ACHE || BCHE

Stucture :

Protein :

References (1)

Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783
Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A
Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021
Abstract : Wichur_2021_Eur.J.Med.Chem_225_113783
ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113783
PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783
PubMedID: 34461507