Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol
IC50: hACHE 76 nM hBCHE 1.204 microM, hBACE1 230 nM
General
Type : anti-Abeta-aggregation,Sulfur Compound,BACE1-inhibitor,Piperidine,Multitarget,Carboxamide,Oxadiazol,Derivative of Donepezil,Cyanide
Chemical_Nomenclature :
Canonical SMILES : [C]1=[C][C]=[C]C(=[C]1)CN2CC[C](CC2)[N]C(=O)CSC3=NN=C(O3)C4=[C]C(=[C][C]=[C]4)C#N
InChI : InChI=1S\/C23H23N5O2S\/c24-14-18-7-4-8-19(13-18)22-26-27-23(30-22)31-16-21(29)25-20-9-11-28(12-10-20)15-17-5-2-1-3-6-17\/h1-8,13,20H,9-12,15-16H2,(H,25,29)
InChIKey : JNPBGTJZEOOGCT-UHFFFAOYSA-N
Other name(s) :
MW : 433.52
Formula : C23H23N5O2S
CAS_number :
PubChem :
UniChem : JNPBGTJZEOOGCT-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ligand of proteins in family: ACHE
Stucture :
Protein :
References (1)
| Title : Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer's Disease Therapy - Waiker_2023_ACS.Chem.Neurosci__ |
| Author(s) : Waiker DK , Verma A , Akhilesh , A GT , Singh N , Roy A , Dilnashin H , Tiwari V , Trigun SK , Singh SP , Krishnamurthy S , Lama P , Davisson VJ , Shrivastava SK |
| Ref : ACS Chem Neurosci , : , 2023 |
| Abstract : Waiker_2023_ACS.Chem.Neurosci__ |
| ESTHER : Waiker_2023_ACS.Chem.Neurosci__ |
| PubMedSearch : Waiker_2023_ACS.Chem.Neurosci__ |
| PubMedID: 37216500 |