Compound-60
In the screen for inhibitors of ABHD2 Compounds 47 and 60 were the most potent ABHD3 inhibitors that remained selective over the other measured
General
Type : Carboxamide
Chemical_Nomenclature :
Canonical SMILES : COc1ccc(CNC(=O)C(F)(F)C(=O)CCc2ccccc2)c(F)c1
InChI : InChI=1S\/C19H18F3NO3\/c1-26-15-9-8-14(16(20)11-15)12-23-18(25)19(21,22)17(24)10-7-13-5-3-2-4-6-13\/h2-6,8-9,11H,7,10,12H2,1H3,(H,23,25)
InChIKey : BFIUHJUREQJWME-UHFFFAOYSA-N
Other name(s) :
MW : 365.35
Formula : C19H18F3NO3
CAS_number :
PubChem :
UniChem : BFIUHJUREQJWME-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : alpha\/beta-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases - Bononi_2021_J.Med.Chem_64_9759 |
| Author(s) : Bononi G , Tuccinardi T , Rizzolio F , Granchi C |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : Bononi_2021_J.Med.Chem_64_9759 |
| ESTHER : Bononi_2021_J.Med.Chem_64_9759 |
| PubMedSearch : Bononi_2021_J.Med.Chem_64_9759 |
| PubMedID: 34213320 |
| Gene_locus related to this paper: human-ABHD3 |
| Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M |
| Ref : ACS Chemical Biology , 14 :2295 , 2019 |
| Abstract : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| ESTHER : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedSearch : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedID: 31525885 |
| Gene_locus related to this paper: human-ABHD2 , human-ABHD3 |