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Inhibitor Report for: Citric-acid

Citric acid is a tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms. It has a role as a food acidity regulator, a chelator, an antimicrobial agent and a fundamental metabolite. It is a conjugate acid of a citrate(1-) and a citrate anion. Anhydrous Citric Acid is found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood.


General
Type
Chemical_Nomenclature 2-hydroxypropane-1,2,3-tricarboxylic acid
Canonical SMILES C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey KRKNYBCHXYNGOX-UHFFFAOYSA-N
Other name(s) DB04272 ; SCHEMBL7206089 ; CH2COOH-C(OH)COOH-CH2COOH ; citric acid ; Citric acid, anhydrous ; Anhydrous citric acid ; CHEBI:30769 ; CHEMBL1261
________________________________________________________________________________________________
MW|192.12
Formula|C6H8O7
CAS_number|77-92-9
PubChem|311, 88113319
UniChem|KRKNYBCHXYNGOX-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Citric-acid ligand of proteins in family: Polyesterase-lipase-cutinase
Stucture | 1 structure: 7E30: Crystal structure of a novel alpha/beta hydrolase in apo form PHL7 PES-H1 in complex with citrate
Protein | 9firm-PHL7

References:
Search PubMed for references concerning: Citric-acid
    Title: Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase
    Pfaff L, Gao J, Li Z, Jackering A, Weber G, Mican J, Chen Y, Dong W, Han X and Wei R <10 more author(s)>
    Ref: ACS Catal, 12:9790, 2022 : PubMed