Carltonine-B
Amaryllidaceae alkaloid carltonine: hBChE IC50 = 0.031 +/- 0.001 microM hAChE IC50 >100 microM || hBChE IC50 = 0.031 +/- 0.001 microM; hAChE IC50 >100 microM
General
Type : Alkaloid,Natural
Chemical_Nomenclature :
Canonical SMILES : C12=CC(=C(C=C1OCO2)CN(CCC3=CC=C(C=C3)O)C)C4=CC=CC5=C4N(CC5)C
InChI : InChI=1S\/C26H28N2O3\/c1-27(12-10-18-6-8-21(29)9-7-18)16-20-14-24-25(31-17-30-24)15-23(20)22-5-3-4-19-11-13-28(2)26(19)22\/h3-9,14-15,29H,10-13,16-17H2,1-2H3
InChIKey : LHQRGHUIBBGUCH-UHFFFAOYSA-N
Other name(s) :
MW : 416.51
Formula : C26H28N2O3
CAS_number :
PubChem :
UniChem : LHQRGHUIBBGUCH-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies - Al Mamun_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Al Mamun A , Pidany F , Hulcova D , Marikova J , Kucera T , Schmidt M , Catapano MC , Hrabinova M , Jun D , Muckova L , Kunes J , Janousek J , Andrys R , Novakova L , Perinova R , Maafi N , Soukup O , Korabecny J , Cahlikova L |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| ESTHER : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedSearch : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34361074 |
| Title : Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity - Kohelova_2020_Bioorg.Chem_107_104567 |
| Author(s) : Kohelova E , Marikova J , Korabecny J , Hulcova D , Kucera T , Jun D , Chlebek J , Jenco J , Safratova M , Hrabinova M , Ritomska A , Malanik M , Perinova R , Breiterova K , Kunes J , Novakova L , Opletal L , Cahlikova L |
| Ref : Bioorg Chem , 107 :104567 , 2020 |
| Abstract : Kohelova_2020_Bioorg.Chem_107_104567 |
| ESTHER : Kohelova_2020_Bioorg.Chem_107_104567 |
| PubMedSearch : Kohelova_2020_Bioorg.Chem_107_104567 |
| PubMedID: 33387730 |