Carltonine-A
Amaryllidaceae alkaloid carltonine: hBChE IC50 = 0.91 +/- 0.02 microM hAChE IC50 >100 microM || hBChE IC50 = 0.91 +/- 0.2 microM; hAChE IC50 >100 microM
General
Type : Alkaloid,Natural
Chemical_Nomenclature :
Canonical SMILES : C1(=CC(=C(C=C1OC)CN(CCC2=CC=C(C=C2)O)C)C3=CC=CC4=C3N(CC4)C)OC
InChI : InChI=1S\/C27H32N2O3\/c1-28(14-12-19-8-10-22(30)11-9-19)18-21-16-25(31-3)26(32-4)17-24(21)23-7-5-6-20-13-15-29(2)27(20)23\/h5-11,16-17,30H,12-15,18H2,1-4H3
InChIKey : CSLQRYJSGRPVQT-UHFFFAOYSA-N
Other name(s) :
MW : 432.56
Formula : C27H32N2O3
CAS_number :
PubChem :
UniChem : CSLQRYJSGRPVQT-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies - Al Mamun_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Al Mamun A , Pidany F , Hulcova D , Marikova J , Kucera T , Schmidt M , Catapano MC , Hrabinova M , Jun D , Muckova L , Kunes J , Janousek J , Andrys R , Novakova L , Perinova R , Maafi N , Soukup O , Korabecny J , Cahlikova L |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| ESTHER : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedSearch : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34361074 |
| Title : Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity - Kohelova_2020_Bioorg.Chem_107_104567 |
| Author(s) : Kohelova E , Marikova J , Korabecny J , Hulcova D , Kucera T , Jun D , Chlebek J , Jenco J , Safratova M , Hrabinova M , Ritomska A , Malanik M , Perinova R , Breiterova K , Kunes J , Novakova L , Opletal L , Cahlikova L |
| Ref : Bioorg Chem , 107 :104567 , 2020 |
| Abstract : Kohelova_2020_Bioorg.Chem_107_104567 |
| ESTHER : Kohelova_2020_Bioorg.Chem_107_104567 |
| PubMedSearch : Kohelova_2020_Bioorg.Chem_107_104567 |
| PubMedID: 33387730 |