CUA
hCE1 IC50 12 nM. a selective inhibitor of human CES1A, near-completely inhibited NLMe hydrolysis in both HumanLiverMicrosome and DogLiverMMicrosome while displayed negligible inhibitory effects on this hydrolytic reaction in other species
General
Type : Terpenoid
Chemical_Nomenclature :
Canonical SMILES : [O]C(CCC(O[C]1C([C@H]2[C@](CC1)([C@@H]3[C@@](CC2)([C@]4([C](CC3)[C@H]5[C]([C](C4)C(=O)[O])CC[C@H]([C]5[C])[C])[C])[C])[C])([C])[C])=O)=O
InChI : InChI=1S\/C34H54O6\/c1-19-8-9-21-22(30(38)39)18-34(7)23(29(21)20(19)2)10-11-25-32(5)16-15-26(40-28(37)13-12-27(35)36)31(3,4)24(32)14-17-33(25,34)6\/h19-26,29H,8-18H2,1-7H3,(H,35,36)(H,38,39)\/t19-,20?,21?,22?,23?,24+,25-,26?,29-,32+,33-,34-\/m1\/s1
InChIKey : DFQIOPCOQAANNS-JYRXSOMGSA-N
Other name(s) : 3beta-O-(beta-Carboxypropionyl)-urs-12-en-28-oic Acid
MW : 558.79
Formula : C34H54O6
CAS_number :
PubChem :
UniChem : DFQIOPCOQAANNS-JYRXSOMGSA-N
IUPHAR :
Wikipedia :
Target
References (3)
| Title : Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate - Jin_2022_Chem.Biol.Interact_368_110197 |
| Author(s) : Jin Q , Li Z , Zhang MJ , Liu WC , Zou LW , Sui H , Wang DD , Tang QF , Ge GB |
| Ref : Chemico-Biological Interactions , 368 :110197 , 2022 |
| Abstract : Jin_2022_Chem.Biol.Interact_368_110197 |
| ESTHER : Jin_2022_Chem.Biol.Interact_368_110197 |
| PubMedSearch : Jin_2022_Chem.Biol.Interact_368_110197 |
| PubMedID: 36174736 |
| Title : Bioluminescent Sensor Reveals that Carboxylesterase 1A is a Novel Endoplasmic Reticulum-Derived Serologic Indicator for Hepatocyte Injury - Wang_2020_ACS.Sens_5_1987 |
| Author(s) : Wang DD , Zou LW , Jin Q , Guan XQ , Yu Y , Zhu YD , Huang J , Gao P , Wang P , Ge GB , Yang L |
| Ref : ACS Sens , 5 :1987 , 2020 |
| Abstract : Wang_2020_ACS.Sens_5_1987 |
| ESTHER : Wang_2020_ACS.Sens_5_1987 |
| PubMedSearch : Wang_2020_ACS.Sens_5_1987 |
| PubMedID: 32529833 |
| Title : Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1 - Zou_2017_Front.Pharmacol_8_435 |
| Author(s) : Zou LW , Dou TY , Wang P , Lei W , Weng ZM , Hou J , Wang DD , Fan YM , Zhang WD , Ge GB , Yang L |
| Ref : Front Pharmacol , 8 :435 , 2017 |
| Abstract : Zou_2017_Front.Pharmacol_8_435 |
| ESTHER : Zou_2017_Front.Pharmacol_8_435 |
| PubMedSearch : Zou_2017_Front.Pharmacol_8_435 |
| PubMedID: 28713276 |