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Inhibitor Report for: CHMP-S-methyl

can be synthetized as (Sp) or (P-) and (Rp) or (P+) stereoisomers


General
Type Organophosphate, Sulfur Compound
Chemical_Nomenclature [methyl(methylsulfanyl)phosphoryl]oxycycloheptane
Canonical SMILES C[P](=O)(OC1CCCCCC1)SC
InChI InChI=1S/C9H19O2PS/c1-12(10,13-2)11-9-7-5-3-4-6-8-9/h9H,3-8H2,1-2H3
InChIKey USEOQBTXEQNYJU-UHFFFAOYSA-N
Other name(s) Cycloheptyl methyl S-methylphosphonylthioate
________________________________________________________________________________________________
MW|222.29
Formula|C9H19O2PS
CAS_number|
PubChem|85590434
UniChem|USEOQBTXEQNYJU-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | CHMP-S-methyl ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: CHMP-S-methyl
    Title: Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates
    Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P
    Ref: Biochemistry, 35:10995, 1996 : PubMed

            

    Title: Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates. Noncovalent determinants of enzyme chirality [published erratum appears in J Biol Chem 1989 Nov 25;264(33):20154]
    Berman HA, Leonard K
    Ref: Journal of Biological Chemistry, 264:3942, 1989 : PubMed

            

    Title: Chiral nature of covalent methylphosphonyl conjugates of acetylcholinesterase
    Berman HA, Decker MM
    Ref: Journal of Biological Chemistry, 264:3951, 1989 : PubMed