CHEMBL48137-49O-4Y2R
Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists
General
Type : Piperazine,Pyridine,Cyanide,Not A\/B H target,Adrenergic-Receptor-ligand
Chemical_Nomenclature : 2-piperazin-1-ylpyridine-3-carbonitrile
Canonical SMILES : C1CN(CCN1)C2=C(C=CC=N2)C#N
InChI : InChI=1S\/C10H12N4\/c11-8-9-2-1-3-13-10(9)14-6-4-12-5-7-14\/h1-3,12H,4-7H2
InChIKey : QSMNQUURWIAXAA-UHFFFAOYSA-N
Other name(s) : CHEMBL48137,2-piperazinonicotinonitrile,2-Piperazin-1-ylnicotinonitrile,2-(piperazin-1-yl)nicotinonitrile,2-(Piperazin-1-Yl)Pyridine-3-Carbonitrile
MW : 188.23
Formula : C10H12N4
CAS_number : 84951-44-0
PubChem : 2737203
UniChem : QSMNQUURWIAXAA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : CHEMBL48137-49O-4Y2R ligand of proteins in family: Epoxide_hydrolase
Stucture : 4Y2R Structure of soluble epoxide hydrolase in complex with 2-(piperazin-1-yl)nicotinonitrile
Protein : human-EPHX2
References (1)
| Title : Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening - Amano_2015_Bioorg.Med.Chem_23_2310 |
| Author(s) : Amano Y , Tanabe E , Yamaguchi T |
| Ref : Bioorganic & Medicinal Chemistry , : , 2015 |
| Abstract : Amano_2015_Bioorg.Med.Chem_23_2310 |
| ESTHER : Amano_2015_Bioorg.Med.Chem_23_2310 |
| PubMedSearch : Amano_2015_Bioorg.Med.Chem_23_2310 |
| PubMedID: 25862210 |
| Gene_locus related to this paper: human-EPHX2 |